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Table 3 Complete analysis using logistic regression in examining the association of log transformed high sensitivity C reactive protein (hsCRP) and dementia

From: The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway

  Total Dementia NCa Combined AD, Mixed AD and Vascular Dementia NCa Alzheimer Disease NCa Mixed AD and Vascular Dementia NCa
(1) Study sample N = 7758 HUNT 2 102 HUNT 2 84 HUNT 2 55 HUNT 2 29
Model 1b 1.55 (1.13-2.12)   1.57 (1.11-2.21)   1.23 (.79-1.90)   2.41 (1.37-4.25)  
Model 2c 1.02 (.72-1.44)   1.01 (.69-1.49)   .74 (.45-1.22)   1.71 (.92-3.19)  
Model 3d 1.03 (.71-1.48)   1.02 (.68-1.52)   .79 (.47-1.31)   1.60 (.84-3.06)  
Model 4e 1.01 (.70-1.45)   1.02 (.68-1.54)   .81 (.48-1.35)   1.55 (.80-2.97)  
hsCRP*Age .98 (.95-1.00)   .98 (.95-1.01)   .98 (.94-1.02)   .98 (.93-1.03)  
hsCRP*Sex .83 (.40-1.72)   .86 (.38-1.93)   .93 (.32-2.69)   .56 (.16-2.03)  
(2) <60f N = 5608   9   7   3   4
Model 1 2.12 (.77-5.85)   1.83 (.57-5.90)   .08 (.00-3.71)   6.00 (1.29-28.00)  
Model 2 1.75 (.59-5.24)   1.40 (.39-5.04)   .06 (.00-2.96)   5.39 (.93-31.18)  
Model 3 2.43 (.79-7.47)   1.87 (.50-7.03)   .06 (.00-7.13)   5.26 (.82-33.72)  
Model 4 1.88 (.58-6.14)   1.53 (.37-6.25)   .05 (.00-8.31)   5.14 (.71-37.45)  
hsCRP*Age 1.06 (.90-1.26)   1.38 (1.01-1.90)   1.00 (.61-1.66)   .86 (.23-3.27)  
hsCRP*Sex .24 (.02-2.69)   .96 (.56-1.63)     .06 (.00-10.03)  
(3) ≥60f N = 2150   93   77   52   25
Model 1 .90 (.62-1.29)   .92 (.62-1.37)   .77 (.47-1.26)   1.33 (.68-2.59)  
Model 2 .89 (.62-1.28)   .91 (.61-1.36)   .75 (.46-1.24)   1.31 (.67-2.58)  
Model 3 .98 (.57-1.67)   .90 (.59-1.37)   .78 (.47-1.32)   1.19 (.46-3.09)  
Model 4 .88 (.60-1.29)   .92 (.61-1.41)   .82 (.49-1.38)   1.21 (.59-2.48)  
hsCRP*Age .96 (.91-1.01)   .95 (.90-1.01)   .93 (.97-.99)   1.01 (.91-1.11)  
hsCRP*Sex .99 (.46-2.12)   .92 (.39-2.14)   .90 (.31-2.64)   .77 (.19-3.17)  
  1. aNumber of dementia cases
  2. bModel 1: log transformed high specificity C-reactive protein (hsCRP)
  3. cModel 2: hsCRP, age, sex, education
  4. dModel 3: hsCRP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, creatinine, body mass index, pulse
  5. eModel 4: SBP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, glomerular filtration rate, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status
  6. fAge when examined in HUNT 2