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Table 3 Complete analysis using logistic regression in examining the association of log transformed high sensitivity C reactive protein (hsCRP) and dementia

From: The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway

 

Total Dementia

NCa

Combined AD, Mixed AD and Vascular Dementia

NCa

Alzheimer Disease

NCa

Mixed AD and Vascular Dementia

NCa

(1) Study sample N = 7758

HUNT 2

102

HUNT 2

84

HUNT 2

55

HUNT 2

29

Model 1b

1.55 (1.13-2.12)

 

1.57 (1.11-2.21)

 

1.23 (.79-1.90)

 

2.41 (1.37-4.25)

 

Model 2c

1.02 (.72-1.44)

 

1.01 (.69-1.49)

 

.74 (.45-1.22)

 

1.71 (.92-3.19)

 

Model 3d

1.03 (.71-1.48)

 

1.02 (.68-1.52)

 

.79 (.47-1.31)

 

1.60 (.84-3.06)

 

Model 4e

1.01 (.70-1.45)

 

1.02 (.68-1.54)

 

.81 (.48-1.35)

 

1.55 (.80-2.97)

 

hsCRP*Age

.98 (.95-1.00)

 

.98 (.95-1.01)

 

.98 (.94-1.02)

 

.98 (.93-1.03)

 

hsCRP*Sex

.83 (.40-1.72)

 

.86 (.38-1.93)

 

.93 (.32-2.69)

 

.56 (.16-2.03)

 

(2) <60f N = 5608

 

9

 

7

 

3

 

4

Model 1

2.12 (.77-5.85)

 

1.83 (.57-5.90)

 

.08 (.00-3.71)

 

6.00 (1.29-28.00)

 

Model 2

1.75 (.59-5.24)

 

1.40 (.39-5.04)

 

.06 (.00-2.96)

 

5.39 (.93-31.18)

 

Model 3

2.43 (.79-7.47)

 

1.87 (.50-7.03)

 

.06 (.00-7.13)

 

5.26 (.82-33.72)

 

Model 4

1.88 (.58-6.14)

 

1.53 (.37-6.25)

 

.05 (.00-8.31)

 

5.14 (.71-37.45)

 

hsCRP*Age

1.06 (.90-1.26)

 

1.38 (1.01-1.90)

 

1.00 (.61-1.66)

 

.86 (.23-3.27)

 

hsCRP*Sex

.24 (.02-2.69)

 

.96 (.56-1.63)

   

.06 (.00-10.03)

 

(3) ≥60f N = 2150

 

93

 

77

 

52

 

25

Model 1

.90 (.62-1.29)

 

.92 (.62-1.37)

 

.77 (.47-1.26)

 

1.33 (.68-2.59)

 

Model 2

.89 (.62-1.28)

 

.91 (.61-1.36)

 

.75 (.46-1.24)

 

1.31 (.67-2.58)

 

Model 3

.98 (.57-1.67)

 

.90 (.59-1.37)

 

.78 (.47-1.32)

 

1.19 (.46-3.09)

 

Model 4

.88 (.60-1.29)

 

.92 (.61-1.41)

 

.82 (.49-1.38)

 

1.21 (.59-2.48)

 

hsCRP*Age

.96 (.91-1.01)

 

.95 (.90-1.01)

 

.93 (.97-.99)

 

1.01 (.91-1.11)

 

hsCRP*Sex

.99 (.46-2.12)

 

.92 (.39-2.14)

 

.90 (.31-2.64)

 

.77 (.19-3.17)

 
  1. aNumber of dementia cases
  2. bModel 1: log transformed high specificity C-reactive protein (hsCRP)
  3. cModel 2: hsCRP, age, sex, education
  4. dModel 3: hsCRP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, creatinine, body mass index, pulse
  5. eModel 4: SBP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, glomerular filtration rate, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status
  6. fAge when examined in HUNT 2