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Fig. 2 | Immunity & Ageing

Fig. 2

From: NK cells of the oldest seniors represent constant and resistant to stimulation high expression of cellular protective proteins SIRT1 and HSP70

Fig. 2

Expression of SIRT1 and intracellular HSP70 in non-stimulated and stimulated NK cells of the young, the old aged under 85 and the oldest seniors (aged over 85). Data are presented as means ± SEM and show expression of the studied proteins in NK cells demonstrated as percentages of cells with the expression of a particular protein (%) or mean fluorescence intensity (MFI). The same symbols over bars (X, +, o, #, *, ^, Δ, Y) denote statistically significant differences between similarly treated NK cells of different age groups (i.e. young vs old; young vs oldest or old vs oldest). Horizontal lines above paired bars denote statistically significant differences between treated and untreated NK cells of the same age group (i.e. non-stimulated vs stimulated with IL-2, LPS or PMA with ionomycin). a Expression of SIRT1 (%): X, #, ^, +, *, Yp < 0.001; op ≤ 0.01. b Expression of SIRT1 (MFI): #, +, *, Yp < 0.001; ^, Xp < 0.01; Δp < 0.05. c Expression of HSP70intracellular (%): X, +, Yp < 0.001; #, *, Δp < 0.01; ^ p < 0.05. d Expression of HSP70intracellular (MFI): #, +, Y, * p ≤ 0.001; X, ^ p ≤ 0.01

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