Table 3 Pre- and post-vaccination GMT values, GMT increase, seroprotection, and seroconversion rates in each IVC against all analysed A/H1N1 and A/H1N1pdm09 viruses
Vaccinated cohorts | ||||||
|---|---|---|---|---|---|---|
Strain/Subtype | Input | Whole period analyzed | 2006-2007 | 2008-2009 | 2009-2010 | 2010-2011 |
Vaccine strain | A/New Caledonia/20/99 | A/Birsbane/59/2007 | A/Birsbane/59/2007 | A/California/07/2009 | ||
A/Weiss/43 | ||||||
Pre-vaccine GMTa(CI95%) | 18.3 (13.5-23.1) | 38.4 (23.6-63.3) | 8.2 (5.1-13.7) | 18.7 (11.0-31.4) | 19.0 (10.2-32.9) | |
Post-vaccine GMT(CI95%) | 44.2 (33.6-52.8) | 83.8 (50.8-143.1) | 24.5 (16.6-37.3) | 45.8 (28.8-73.7) | 39.4 (21.0-68.0) | |
GMT increase | 2.4 | 2.2 | 3.0 | 2.4 | 2.1 | |
SPRb | 63.2 | 84.4 | 46.5 | 65.1 | 55.8 | |
SCRc | 16.1 | 24.4 | 14.0 | 16.3 | 9.3 | |
A/FM/1/47 | ||||||
Pre-vaccine GMT(CI95%) | 7.8 (6.3-9.8) | 7.8 (4.9-13.0) | 3.4 (2.2-5.1) | 12.5 (8.7-18.1) | 11.3 (7.6-16.7) | |
Post-vaccine GMT(CI95%) | 13.6 (10.6-17.4) | 20.5(13.7-31.0) | 4.6 (2.9-7.1) | 15.3 (10.4-22.6) | 23.1 (13.6-37.0) | |
GMT increase | 1.7 | 2.6 | 1.4 | 1.2 | 2.0 | |
SPR | 31.0 | 35.6 | 14 | 30.2 | 44.2 | |
SCR | 13.2 | 11.1 | 4.7 | 7 | 30.2 | |
A/New Caledonia/20/99 | ||||||
A/Brisbane/59/2007 | ||||||
Pre-vaccine GMT(CI95%) | 20.9 (16.6-25.1) | 34.5 (27.6-51.2) | 13.6 (8.3-21.1) | 13.2 (8.6-19.8) | 29.8 (21.7-39.8) | |
Post-vaccine GMT(CI95%) | 63.8 (53.1-77.6) | 112.3(69.7-145.8) | 103.5 (72.3-147.4) | 27.8 (19.5-37.4) | 50.1 (37.9-66.7) | |
GMT increase | 3.1 | 3.3 | 7.6 | 2.1 | 1.7 | |
SPR | 73.0 | 82.2 | 83.7 | 58.1 | 67.4 | |
SCR | 33.9 | 42.2 | 60.5 | 16.3 | 16.3 | |
A/H1N1pdm09 | ||||||
Pre-vaccine GMT(CI95%) | 1.8 (1.5-2.1) | 1.5 (1.2-1.9) | 1.6 (1.1-2.3) | 1.9 (1.3-2.6) | 2.4 (1.7-3.7) | |
Post-vaccine GMT(CI95%) | 12.7 (9.5-17.2) | 5.4 (3.4-8.7) | 7.5 (4.8-11.2) | 7.2 (4.2-11.9) | 93.0 (54.3-150.0) | |
GMT increase | 7.1 | 3.6 | 4.7 | 3.8 | 38.8 | |
SPR | 35.6 | 13.3 | 20.9 | 23.3 | 86 | |
SCR | 31.6 | 13.3 | 14 | 20.9 | 79.1 | |