Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Signature Pathways Altered Between the Drug-User and Non-User Cohorts based on the significant DE genes. Pathway enrichments were assessed using the Laboratory of Immunopathogenesis and Bioinformatics resource, DAVID. Only Pathway associations with a p-value < 0.05 and an FDR < 10% were considered statistically noteworthy

From: Immune response to influenza vaccination in the elderly is altered by chronic medication use

Top Canonical Pathways associated with DE genes FDR (%) p-value
METFORMIN
 Extracellular Exosome 6.2 2.5 × 10–3
 LPS/IL-1 Mediated Inhibition of RXR Function 8.1 1.1 × 10–3
 Histamine Biosynthesis 8.1 2.0 × 10–3
 Protein Digestion 8.5 2.8 × 10–4
NSAIDS
 Antiviral Defense 2 × 10–2 5.6 × 10–7
 Cell Division and Chromosome Partitioning 9.8 × 10–2 6.6 × 10–6
 type I interferon signaling pathway 0.16 3.2 × 10–6
 Inhibition of Viral Genome Replication 2.2 3.5 × 10–5
 Innate Immunity 5.7 4.7 × 10–4
STATIN
 Antigen Presentation Pathway 1 × 10–3 1.5 × 10–7
 Interferon-gamma-mediated signaling pathway 1.9 × 10–3 2.9 × 10–8
 Regulation of interleukin-10 secretion 5.1 × 10–3 2 × 10–9
 OX40 Signaling Pathway 8.7 × 10–3 5.2 × 10–6
 Regulation of interleukin-4 production 1 × 10–2 7.8 × 10–9
 B Cell Development 1.5 × 10–2 1.2 × 10–5
 Cdc42 Signaling 3.4 × 10–2 5.7 × 10–5
 Nur77 Signaling in T Lymphocytes 3.4 × 10–2 5.7 × 10–5
 Th1 and Th2 Activation Pathway 4.3 × 10–2 8.7 × 10–5
 Dendritic Cell Maturation 4.6 × 10–2 1 × 10–4
 iCOS-iCOSL Signaling in T Helper Cells 0.17 5.1 × 10–4
 CD28 Signaling in T Helper Cells 0.19 6.3 × 10–4
 Phagosome Maturation 0.26 8.7 × 10–4
 PKCtheta Signaling in T Lymphocytes 0.3 1.1 × 10–3
 Role of NFAT in Regulation of the Immune Response 0.46 1.7 × 10–3
 Role of JAK family kinases in IL-6-type Cytokine Signaling 7.1 3.1 × 10–2