Table 1 Comparison of the analyzed parameters between similarly treated CD56dim and CD56bright cells of the same age group
Parameter | Stimulation type | CD56dim vs. CD56bright | |||||
|---|---|---|---|---|---|---|---|
young | old | oldest | |||||
% | MFI | % | MFI | % | MFI | ||
SIRT1 | ns | ** ↑ bright | – | *** ↑ dim | – | – | – |
IL2 | – | ** ↑ bright | – | – | – | – | |
LPS | *** ↑ bright | – | * ↑ bright | – | – | – | |
PMA/ion | – | *** ↑ bright | – | – | – | – | |
HSP70intr | ns | – | – | – | – | – | – |
IL2 | * ↑ bright | ** ↑ bright | – | – | – | – | |
LPS | – | – | – | – | – | – | |
PMA/ion | * ↑ bright | ** ↑ bright | – | ** ↑ bright | – | – | |
HSP70surf | ns | *** ↑ dim | *** ↑ dim | *** ↑ bright | *** ↑ dim | *** ↑ dim | *** ↑ dim |
IL2 | – | – | *** ↑ dim | – | * ↑ dim | – | |
LPS | *** ↑ bright | * ↑ dim | *** ↑ dim | – | *** ↑ dim | – | |
PMA/ion | *** ↑ dim | *** ↑ dim | – | – | – | – | |
SOD2 | ns | – | – | ** ↑ dim | – | – | – |
IL2 | – | – | – | * ↑ bright | *** ↑ bright | ** ↑ bright | |
LPS | – | – | – | – | ** ↑ bright | – | |
PMA/ion | – | – | – | – | – | – | |
TNF | ns | *** ↑ bright | *** ↑ dim | *** ↑ dim | *** ↑ dim | *** ↑bright | ** ↑dim |
IL2 | – | *** ↑ dim | – | *** ↑ dim | – | – | |
LPS | *** ↑ dim | *** ↑ dim | *** ↑dim | *** ↑ dim | *** ↑ dim | ** ↑ dim | |
PMA/ion | *** ↑ dim | *** ↑ dim | *** ↑dim | *** ↑ dim | *** ↑ dim | ** ↑ dim | |
IFN-γ | ns | – | – | *** ↑ dim | – | – | – |
IL2 | – | – | – | – | – | – | |
LPS | – | – | ** ↑ dim | – | – | – | |
PMA/ion | – | * ↑ dim | – | – | * ↑ bright | – | |