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Table 1 Comparison of the analyzed parameters between similarly treated CD56dim and CD56bright cells of the same age group

From: CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2

Parameter Stimulation type CD56dim vs. CD56bright
young old oldest
% MFI % MFI % MFI
SIRT1 ns **
↑ bright
***
↑ dim
IL2 **
↑ bright
LPS ***
↑ bright
*
↑ bright
PMA/ion ***
↑ bright
HSP70intr ns
IL2 *
↑ bright
**
↑ bright
LPS
PMA/ion *
↑ bright
**
↑ bright
**
↑ bright
HSP70surf ns ***
↑ dim
***
↑ dim
***
↑ bright
***
↑ dim
***
↑ dim
***
↑ dim
IL2 ***
↑ dim
*
↑ dim
LPS ***
↑ bright
*
↑ dim
***
↑ dim
***
↑ dim
PMA/ion ***
↑ dim
***
↑ dim
SOD2 ns **
↑ dim
IL2 *
↑ bright
***
↑ bright
**
↑ bright
LPS **
↑ bright
PMA/ion
TNF ns ***
↑ bright
***
↑ dim
***
↑ dim
***
↑ dim
***
↑bright
**
↑dim
IL2 ***
↑ dim
***
↑ dim
LPS ***
↑ dim
***
↑ dim
***
↑dim
***
↑ dim
***
↑ dim
**
↑ dim
PMA/ion ***
↑ dim
***
↑ dim
***
↑dim
***
↑ dim
***
↑ dim
**
↑ dim
IFN-γ ns ***
↑ dim
IL2
LPS **
↑ dim
PMA/ion *
↑ dim
*
↑ bright
  1. ↑denotes significantly higher expression in dim or bright cells
  2. 'HSP70intr' intracellular HSP70, 'HSP70surf' surface HSP70, 'PMA/ion' PMA + ionomycin
  3. *** p < 0.001; ** p < 0.01; * p < 0.05