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Table 1 Upstream regulators in colon identified by Ingenuity pathway analysis based on the comparison between Ercc1−/Δ7 mice receiving A. muciniphila supplementation and control mice

From: Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

Upstream Regulator Activation z-score p-value of overlap
ACOX1 2.24 0.013
Alpha catenin 2.00 0.029
ID3 1.98 0.030
SOCS1 1.95 0.040
CDKN2A 1.72 0.025
MYD88 −2.41 0.045
IL1 −2.38 0.049
TNFRSF1B −2.22 0.003
CHUK −2.21 0.017
GATA6 −2.21 0.036
NFKBIA −2.17 0.029
Akt −2.16 0.020
cytokine −1.99 0.000
Nfat (family) −1.98 0.014
CCND1 −1.98 0.044
WNT5A −1.95 0.033
CTNNB1 −1.95 0.037
Tgf beta −1.94 0.010
EGR1 −1.91 0.035
Interferon alpha −1.78 0.004
LTBR −1.72 0.001
STAT3 −1.71 0.024
TCR −1.60 0.029
TNFSF12 −1.58 0.004
TNF −1.54 0.036
SSB −1.52 0.000
IL17A −1.40 0.002
TICAM1 −1.40 0.003
HRAS −1.39 0.031
E2F1 −1.36 0.009
IL6 −1.34 0.005
PRKACA −1.21 0.001
IL1B −1.21 0.003
  1. Cut-off values include p < 0.05 and activation z-score < − 1.2 or > 1.2. Upstream regulators in bold are involved in inflammation- and immune-related processes