Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

Table 3 Correlations for cytokine concentrations^a with BMI, WC, hsCRP, and sports adjusted for age and sex

Biomarker	BMI (kg/cm²)			Waist Circumference (cm)			hsCRP (ug/ml)			Reported sports activities^b (hours/week)
Biomarker	N	ρ^c	95% CI^d	N	ρ^c	95% CI^d	N	ρ^c	95% CI^d	N	ρ^c	95% CI^d
IL-1β	102	−0.19	− 0.37, 0.01	102	−0.15	− 0.33, 0.05	76	0.06	−0.17, 0.28	79	0.09	−0.14, 0.3
P-value		0.06			0.15			0.62			0.46
IL-2	159	0.04	−0.11, 0.2	159	0.08	−0.07, 0.24	126	−0.02	− 0.2, 0.15	143	0.07	−0.1, 0.23
P-value		0.59			0.30			0.78			0.42
IL-4	175	−0.06	−0.21, 0.09	175	−0.06	−0.21, 0.09	137	0.03	−0.14, 0.2	143	0.03	−0.14, 0.19
P-value		0.44			0.69			0.42			0.76
IL-6	207	0.36	0.23, 0.47	207	0.41	0.28, 0.51	164	0.53	0.41, 0.63	207	−0.12	−0.26, 0.01
P-value		<.0001			<.0001			<.0001			0.08
IL-8	207	0.05	−0.08, 0.19	207	0.04	−0.1, 0.18	164	0.06	−0.1, 0.21	207	0	−0.14, 0.14
P-value		0.44			0.58			0.46			0.98
IL-10	207	0	−0.14, 0.13	207	0.02	−0.12, 0.15	164	0.19	0.03, 0.33	207	0.04	−0.1, 0.17
P-value		0.96			0.82			0.02			0.60
IL-12p70	205	0.06	−0.08, 0.19	205	0.10	−0.04, 0.23	162	−0.02	− 0.17, 0.14	194	0.07	−0.08, 0.21
P-value		0.43			0.16			0.82			0.36
IL-13	191	0.06	−0.09, 0.2	191	0.06	−0.09, 0.2	152	0.12	−0.04, 0.28	167	0.04	−0.12, 0.19
P-value		0.44			0.45			0.14			0.63
IFN-γ	207	0.04	−0.1, 0.17	207	0.09	−0.05, 0.22	164	0.23	0.08, 0.37	207	0.01	−0.12, 0.15
P-value		0.60			0.22			0.004			0.84
TNF- α	207	0.20	0.07, 0.33	207	0.16	0.03, 0.29	164	0.22	0.07, 0.36	207	−0.15	−0.28, −0.02
P-value		0.004			0.02			0.004			0.03

^aMean cytokine concentrations from both measurements ^bSports in winter with first blood sample from October–March. ^cSpearman partial correlation coefficient. ^dBased on Fisher’s z transformation Abbreviations: BMI Body mass index, CI Confidence interval, hsCRP High sensitivity c-reactive protein, IL-1β Interleukin 1-beta, IL-2 Interleukin 2, IL-4 Interleukin 4, IL-8 Interleukin 8, IL-10 Interleukin 10, IL-12p70 Interleukin 12p70, IL-13 Interleukin 13, IFN-γ Interferon gamma, IQR Interquartile range, TNF-α Tumor necrosis factor alpha, WC Waist circumference

ISSN: 1742-4933