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Table 4 ICCs with 95% CIs of inflammatory cytokines in predominantly healthy participants previously published in literature

From: Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

Reference

Assay

Cytokines

IL-1β

IL-2

IL-4

IL-6

IL-8

IL-10

IL-12p70

IL-13

IFN-γ

TNF-α

This study

MSD

0.25

(0.02, 0.44)

0.32

(0.16, 0.46)

−0.18

(− 0.34, − 0.02)

0.60

(0.51, 0.68)

0.64

(0.55, 0.71)

0.58

(0.48, 0.66)

0.35

(0.22, 0.47)

0.43

(0.30, 0.55)

0.40

(0.28, 0.51)

0.70

(0.63, 0.77)

McKay et al. 2017 [11]

MSD

ND

ND

0.60

(0.51, 0.68)

0.85

(0.81, 0.88)

0.84

(0.79, 0.87)

ND

0.54

(0.46, 0.63)

Belzeaux et al. 2017 [12]

MSD

ND

ND

0.04

−0.01

0.12

0.83

ND

0.07

0.74

 

Luminex

0.96

0.90

0.95

0.89

0.96

0.89

0.90

0.97

0.96

Epstein et al. 2013 [13]

Luminex

0.49

(0.41, 0.62)

0.55

(0.47, 0.62)

0.34

(0.25, 0.43)

0.70

(0.64, 0.75)

0.55

(0.47, 0.62)

0.87

(0.84, 0.90)

Todd et al. 2013 [14]

Erenna Immunoassay Systema

0.46

  

0.39

Nash et al. 2013 [15]

ELISA

0.72

Navarro et al. 2012 [16]

ELISA/

Luminexb

0.48

(0.36, 0.62)

0.73

(0.63, 0.83)

0.92

(0.89, 0.96)

Hofmann et al. 2011 [17]

Luminex

ND

ND

ND

0.84

(0.70, 0.91)

0.55

(0.28, 0.71)

0.60

(0.35, 0.76)

ND

0.73

(0.52, 0.85)

ND

0.86

(0.74, 0.93)

Clendenen et al. 2010 [18]

Luminex

0.73

(0.43, 0.89)

0.80

(0.56, 0.92)

0.70

(0.36, 0.87)

0.81

(0.56, 0.92)

0.86

(0.68, 0.95)

0.75

(0.46, 0.90)

0.77

(0.50, 0.91)

0.81

(0.56, 0.92)

0.72

(0.41, 0.89)

0.69

(0.36, 0.87)

Gu et al. 2009 [19]

Luminex

0.86

(0.78, 0.91)

0.81

(0.71, 0.88)

0.92

(0.87, 0.95)

0.92

(0.88, 0.95)

0.02

(0.00, 0.21)

0.75

(0.63, 0.84)

0.83

(0.74, 0.89)

0.88

(0.82, 0.92)

Lee et al. 2007 [20]

Luminex

0.77

0.73

0.51

0.48

  1. aLaboratory developed tests based upon single-molecule counting technology. bIL-6 was measured with ELISA, IL-8 and TNF-α with Luminex. Abbreviations: ICC Intraclass correlation coefficient, IL-1β Interleukin 1-beta, IL-2 Interleukin 2, IL-4 Interleukin 4, IL-8 Interleukin 8, IL-10 Interleukin 10, IL-12p70 Interleukin 12p70, IL-13 Interleukin 13, IFN-γ Interferon gamma, MSD Meso Scale Discovery, TNF-α Tumor necrosis factor alpha, ND Not determined for analytes with low % detected (usually < 40% samples above LLOD or high coefficients of variability of duplicates)