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Table 4 ICCs with 95% CIs of inflammatory cytokines in predominantly healthy participants previously published in literature

From: Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

Reference Assay Cytokines
IL-1β IL-2 IL-4 IL-6 IL-8 IL-10 IL-12p70 IL-13 IFN-γ TNF-α
This study MSD 0.25
(0.02, 0.44) 		0.32
(0.16, 0.46) 		−0.18
(− 0.34, − 0.02) 		0.60
(0.51, 0.68) 		0.64
(0.55, 0.71) 		0.58
(0.48, 0.66) 		0.35
(0.22, 0.47) 		0.43
(0.30, 0.55) 		0.40
(0.28, 0.51) 		0.70
(0.63, 0.77)
McKay et al. 2017 [11] MSD ND ND – 0.60
(0.51, 0.68) 		– 0.85
(0.81, 0.88) 		0.84
(0.79, 0.87) 		– ND 0.54
(0.46, 0.63)
Belzeaux et al. 2017 [12] MSD ND – ND 0.04 −0.01 0.12 0.83 ND 0.07 0.74
  Luminex 0.96 – 0.90 0.95 0.89 0.96 0.89 0.90 0.97 0.96
Epstein et al. 2013 [13] Luminex 0.49
(0.41, 0.62) 		– – 0.55
(0.47, 0.62) 		0.34
(0.25, 0.43) 		0.70
(0.64, 0.75) 		– – 0.55
(0.47, 0.62) 		0.87
(0.84, 0.90)
Todd et al. 2013 [14] Erenna Immunoassay Systema – – – 0.46 –    – – 0.39
Nash et al. 2013 [15] ELISA – – – 0.72 – – – – – –
Navarro et al. 2012 [16] ELISA/
Luminexb 		– – – 0.48
(0.36, 0.62) 		0.73
(0.63, 0.83) 		– – – – 0.92
(0.89, 0.96)
Hofmann et al. 2011 [17] Luminex ND ND ND 0.84
(0.70, 0.91) 		0.55
(0.28, 0.71) 		0.60
(0.35, 0.76) 		ND 0.73
(0.52, 0.85) 		ND 0.86
(0.74, 0.93)
Clendenen et al. 2010 [18] Luminex 0.73
(0.43, 0.89) 		0.80
(0.56, 0.92) 		0.70
(0.36, 0.87) 		0.81
(0.56, 0.92) 		0.86
(0.68, 0.95) 		0.75
(0.46, 0.90) 		0.77
(0.50, 0.91) 		0.81
(0.56, 0.92) 		0.72
(0.41, 0.89) 		0.69
(0.36, 0.87)
Gu et al. 2009 [19] Luminex 0.86
(0.78, 0.91) 		0.81
(0.71, 0.88) 		0.92
(0.87, 0.95) 		0.92
(0.88, 0.95) 		0.02
(0.00, 0.21) 		0.75
(0.63, 0.84) 		0.83
(0.74, 0.89) 		– – 0.88
(0.82, 0.92)
Lee et al. 2007 [20] Luminex 0.77 – – 0.73 0.51 – – – – 0.48
  1. aLaboratory developed tests based upon single-molecule counting technology. bIL-6 was measured with ELISA, IL-8 and TNF-α with Luminex. Abbreviations: ICC Intraclass correlation coefficient, IL-1β Interleukin 1-beta, IL-2 Interleukin 2, IL-4 Interleukin 4, IL-8 Interleukin 8, IL-10 Interleukin 10, IL-12p70 Interleukin 12p70, IL-13 Interleukin 13, IFN-γ Interferon gamma, MSD Meso Scale Discovery, TNF-α Tumor necrosis factor alpha, ND Not determined for analytes with low % detected (usually < 40% samples above LLOD or high coefficients of variability of duplicates)
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