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Table 1 Characterization of the study population. Comparisons between groups regarding the vaccine response to the influenza vaccine

From: Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people

Variable TOTAL N = 60 Non-Responders N = 33 Responders N = 27 p
Age (years) 79 [70–87] 80 [67–88] 77 [71–86] 0.806
Male sex, n (%) 24 (40) 15 (46) 9 (33) 0.340
CD4 + T-cell count (cells/mm 3 ) 799 [614–1103] 715 [533–1236] 825 [749–1008] 0.281
CD8 + T-cell count (cells/mm 3 ) 473 [279–685] 439 [159–671] 486 [384–698] 0.185
CD4 + /CD8 + ratio 1.8 [1.2–2.3] 1.9 [1.2–2.3] 1.6 [1.1–2.7] 0.704
sj/β TREC ratio 32 [0–50] 31 [0–55] 34 [7–50] 0.615
Thymic failure a 19 (32) 12 (36) 7 (27) 0.441
CMV titre (AU/μL) 25.4 [13.3–40.3] 25.4 [12.4–39.0] 24.6 [13.8–43.0] 0.973
LBP (ng/μL) 12.7 [10.2–14.1] 13.0 [10.1–15.3] 12.7 [11.4–13.5] 0.564
hsCRP (mg/L) 2.8 [1.6–5.0] 2.3 [1.2–4.8] 3.1 [2.2–5.0] 0.330
B2M (μg/mL) 2.5 [2.1–3.5] 2.7 [2.4–3.7] 2.3 [2.0–3.3] 0.156
D-dimers (μg/L) 705 [438–1183] 875 [445–1425] 620 [438–918] 0.082
IL-6 (pg/mL) 3.5 [2.4–4.6] 3.4 [2.3–4.9] 3.6 [2.6–4.5] 0.691
sCD163 (ng/L) 1034 [844–1293] 1034 [792–1224] 1084 [878–1477] 0.222
% Lymphocytes 26.2 [23.2–33.1] 24.9 [22.4–32.0] 29.0 [25.0–34.1] 0.063
% Monocytes 6.5 [5.4–7.6] 6.6 [5.4–7.9] 6.5 [5.4–7.5] 0.894
% Neutrophils 59.6 [54.1–65.7] 62.8 [54.4–66.9] 58.0 [52.4–62.5] 0.089
% Basophils 0.2 [0.2–0.4] 0.3 [0.2–0.4] 0.2 [0.1–0.3] 0.258
% Eosinophils 3.4 [2.2–4.2] 3.2 [1.7–4.5] 3.7 [3.2–4.2] 0.094
Platelets (x10e9/L) 223 [180–294] 233 [181–294] 197 [170–296] 0.650
MCV (fL) 90.2 [86.1–93.6] 90.6 [85.5–93.5] 90.0 [86.6–95.1] 0.876
MPV (fL) 9.4 [7.9–10.1] 9.3 [7.8–10.3] 9.40 [8.1–10.0] 0.716
ESR (mm/h) 12 [6–22] 14 [6–21] 10 [6–24] 0.921
PLR 117 [87–164] 134 [88–166] 113 [82–144] 0.377
NLR 2.3 [1.6–2.9] 2.6 [1.7–3.0] 1.9 [1.5–2.4] 0.056
Comorbidities (number b ) 3 [2–5] 3 [2–5] 3 [2–5] 0.874
Barthel index c 87 [70–100] 85 [70–100] 90 [70–100] 0.838
<  20 3 (5) 1 (3.8) 2 (6.1)  
20–35 2 (3.3) 1 (3.8) 1 (3)  
40–55 5 (8.3) 3 (11.5) 2 (6.1)  
≥ 60 32 (53.3) 14 (53.8) 18 (54.5)  
100 18 (30) 8 (29.6) 10 (30.3)  
  1. Continuous variables are expressed as median values [IQR], and categorical variables are expressed as the number of cases (%). Comparisons between the groups were made using the nonparametric Mann–Whitney U test for continuous variables and the χ2 or Fisher exact test for categorical variables. Variables with a p value < 0.1 are shown in italics. Variables with a p value < 0.05 were considered statistically significant and are shown in bold. Note: CMV Cytomegalovirus, LBP Lipopolysaccharide Binding Protein, hsCRP High sensitivity C-Reactive Protein, B2M β2-microglobulin, sCD163 soluble CD163, MCV Mean corpuscular volume, MPV Mean platelet volume, ESR erythrocyte sedimentation rate, PLR Platelet to lymphocyte ratio, and NLR Neutrophil to lymphocyte ratio. (a) Thymic failure is defined as an sj/β TREC ratio < 10. bDetails of comorbidities recorded are shown in Additional file 5: Table S5. c100 is totally independent and < 20 is totally dependent