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Table 1 Characterization of the study population. Comparisons between groups regarding the vaccine response to the influenza vaccine

From: Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people

Variable

TOTAL

N = 60

Non-Responders

N = 33

Responders

N = 27

p

Age (years)

79 [70–87]

80 [67–88]

77 [71–86]

0.806

Male sex, n (%)

24 (40)

15 (46)

9 (33)

0.340

CD4 + T-cell count

(cells/mm 3 )

799 [614–1103]

715 [533–1236]

825 [749–1008]

0.281

CD8 + T-cell count

(cells/mm 3 )

473 [279–685]

439 [159–671]

486 [384–698]

0.185

CD4 + /CD8 + ratio

1.8 [1.2–2.3]

1.9 [1.2–2.3]

1.6 [1.1–2.7]

0.704

sj/β TREC ratio

32 [0–50]

31 [0–55]

34 [7–50]

0.615

Thymic failure a

19 (32)

12 (36)

7 (27)

0.441

CMV titre (AU/μL)

25.4 [13.3–40.3]

25.4 [12.4–39.0]

24.6 [13.8–43.0]

0.973

LBP (ng/μL)

12.7 [10.2–14.1]

13.0 [10.1–15.3]

12.7 [11.4–13.5]

0.564

hsCRP (mg/L)

2.8 [1.6–5.0]

2.3 [1.2–4.8]

3.1 [2.2–5.0]

0.330

B2M (μg/mL)

2.5 [2.1–3.5]

2.7 [2.4–3.7]

2.3 [2.0–3.3]

0.156

D-dimers (μg/L)

705 [438–1183]

875 [445–1425]

620 [438–918]

0.082

IL-6 (pg/mL)

3.5 [2.4–4.6]

3.4 [2.3–4.9]

3.6 [2.6–4.5]

0.691

sCD163 (ng/L)

1034 [844–1293]

1034 [792–1224]

1084 [878–1477]

0.222

% Lymphocytes

26.2 [23.2–33.1]

24.9 [22.4–32.0]

29.0 [25.0–34.1]

0.063

% Monocytes

6.5 [5.4–7.6]

6.6 [5.4–7.9]

6.5 [5.4–7.5]

0.894

% Neutrophils

59.6 [54.1–65.7]

62.8 [54.4–66.9]

58.0 [52.4–62.5]

0.089

% Basophils

0.2 [0.2–0.4]

0.3 [0.2–0.4]

0.2 [0.1–0.3]

0.258

% Eosinophils

3.4 [2.2–4.2]

3.2 [1.7–4.5]

3.7 [3.2–4.2]

0.094

Platelets (x10e9/L)

223 [180–294]

233 [181–294]

197 [170–296]

0.650

MCV (fL)

90.2 [86.1–93.6]

90.6 [85.5–93.5]

90.0 [86.6–95.1]

0.876

MPV (fL)

9.4 [7.9–10.1]

9.3 [7.8–10.3]

9.40 [8.1–10.0]

0.716

ESR (mm/h)

12 [6–22]

14 [6–21]

10 [6–24]

0.921

PLR

117 [87–164]

134 [88–166]

113 [82–144]

0.377

NLR

2.3 [1.6–2.9]

2.6 [1.7–3.0]

1.9 [1.5–2.4]

0.056

Comorbidities (number b )

3 [2–5]

3 [2–5]

3 [2–5]

0.874

Barthel index c

87 [70–100]

85 [70–100]

90 [70–100]

0.838

<  20

3 (5)

1 (3.8)

2 (6.1)

 

20–35

2 (3.3)

1 (3.8)

1 (3)

 

40–55

5 (8.3)

3 (11.5)

2 (6.1)

 

≥ 60

32 (53.3)

14 (53.8)

18 (54.5)

 

100

18 (30)

8 (29.6)

10 (30.3)

 
  1. Continuous variables are expressed as median values [IQR], and categorical variables are expressed as the number of cases (%). Comparisons between the groups were made using the nonparametric Mann–Whitney U test for continuous variables and the χ2 or Fisher exact test for categorical variables. Variables with a p value < 0.1 are shown in italics. Variables with a p value < 0.05 were considered statistically significant and are shown in bold. Note: CMV Cytomegalovirus, LBP Lipopolysaccharide Binding Protein, hsCRP High sensitivity C-Reactive Protein, B2M β2-microglobulin, sCD163 soluble CD163, MCV Mean corpuscular volume, MPV Mean platelet volume, ESR erythrocyte sedimentation rate, PLR Platelet to lymphocyte ratio, and NLR Neutrophil to lymphocyte ratio. (a) Thymic failure is defined as an sj/β TREC ratio < 10. bDetails of comorbidities recorded are shown in Additional file 5: Table S5. c100 is totally independent and < 20 is totally dependent