Table 3 Characteristics during hospital stay
From: Systemic infection and microglia activation: a prospective postmortem study in sepsis patients
Control N = 15 | Sepsis N = 16 | p-value | |
|---|---|---|---|
Hospital admission | |||
Reason for admission. N (%) | |||
Cardiac | 9 (60.0) | 2 (12.5) | |
Infection | 0 | 7 (43.8) | |
Elective surgery | 3 (20.0) | 2 (12.5) | |
Emergency surgery | 0 | 1 (6.3) | |
Other medical | 3 (20.0) | 4 (25.0) | |
Ward. N (%) | |||
Cardiology | 5 (33.3) | 0 | |
Intensive care unit | 2 (13.3) | 15 (93.8) | |
Emergency room | 2 (13.3) | 0 | |
Internal medicine | 2 (13.3) | 1 (6.3) | |
Other | 4 (26.6) | 0 | |
Complications during hospital stay | |||
AKI. N (%) | 1 (6.7) | 10 (62.5) | < 0.001 |
ARDS. N (%) | 1 (6.7) | 7 (43.8) | 0.013 |
Thrombocytopenia. N (%) | 1 (6.7) | 8 (50) | 0.010 |
DIC. N (%) | 0 | 12 (75) | < 0.001 |
Shock N (%) | 10 (66.7) | 16 (100) | 0.018 |
Septic | 0 | 16 (100) | |
Cardiogenic | 8 (53.3) | 0 | |
Obstructive | 1 (6.7) | 0 | |
Hypovolemic | 1 (6.7) | 0 | |
Interventions during hospital stay | |||
Mechanical ventilation. N (%) | 2 (13.3) | 12 (75.0) | 0.001 |
RRT. N (%) | 0 | 7 (43.8) | 0.007 |
Surgery. N (%) | 3 (20.0) | 7 (43.8) | 0.152 |
Resuscitation. N (%) | 9 (60.0) | 6 (37.5) | 0.186 |
Vasoactive medication | 3 (20.0) | 15 (81.3) | < 0.001 |
Infection and treatment | |||
At least 1 positive culture. N (%) | 7 (46.7) | 16 (100.0) | 0.001 |
Bacteremia | 0 | 8 (50.0) | |
Abdomen | 0 | 8 (8.0) | |
Respiratory tract | 3 (20.0) | 7 (43.8) | |
Urogenital tract | 4 (26.7) | 2 (12.5) | |
Peripheral | 0 | 2 (12.5) | |
Cardiac | 0 | 1 (6.3) | |
N different microorganisms. Median (IQR) | 0 (0.0–1.0) | 1.5 (1.0–2.0) | 0.003 |
Patients with antimicrobial therapy. N (%) | 5 (33.3) | 13 (81.3) | 0.011 |
Defined daily doses. Median (IQR) | 0 (0.0–0.7) | 2.2 (1.0–3.3) | 0.002 |
Death | |||
Cause of death. N (%) | |||
Cardiac/hemodynamic | 14 (93.3) | 2 (12.5) | < 0.001 |
Respiratory | 1 (6.7) | 0 | |
MOF | 0 | 13 (81.3) | |
Other | 0 | 1 (6.3) | |
Hospital stay, days. Median (IQR) | 2.2 (1.2–8.2) | 5.9 (2.1–14.6) | 0.142 |
Active malignancy at death. N (%) | 0 | 4 (25.0) | 0.101 |
Hours between death and autopsy. Median (IQR) | 21.7 (11.8–27.3) | 18.4 (11.3–33.2) | 0.608 |