Fig. 2

Volcano plots of all quantified genes in the transcriptome analysis of peripheral blood mononuclear cells of patients with neovascular AMD with subretinal fibrosis compared to those without. Significantly differentially expressed genes are defined as those with at least ±30% change (level of magnitude, vertical lines) and P < 0.05 (level of statistical significance, horizontal line) and illustrated in red (increased expression) or blue (decreased expression). The two genes with highest increase or decrease are stated with names. P-values are obtained using analysis of covariance including run date, age, and sex as co-variates and with patients with subretinal fibrosis versus patients without subretinal fibrosis as contrast. P-values are logarithmic transformed for plot construction