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Table 2 Significantly differentially expressed genes in peripheral blood mononuclear cells of patients with different clinical subtypes of late AMD

From: The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration

Gene name Description FC % P-value
Patients with GA
 SNORA14A small nucleolar RNA, H/ACA box 14A 101 0.031
 USP32P1 ubiquitin specific peptidase 32 pseudogene 1 67 < 0.001
 SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 62 0.002
 MIR4516 microRNA 4516 59 0.020
 DDA1 DET1 and DDB1 associated 1 46 0.033
 MIR3665 microRNA 3665 44 < 0.001
 SNORA49 small nucleolar RNA, H/ACA box 49 43 0.025
 MIR4509–1 microRNA 4509–1 39 0.024
 TMEM120A transmembrane protein 120A 38 0.004
 LY6E lymphocyte antigen 6 complex, locus E 35 0.021
 IFITM1 interferon induced transmembrane protein 1 35 0.033
 CSNK1G2 casein kinase 1, gamma 2 34 0.015
 NINJ1 ninjurin 1 33 0.003
 HSH2D hematopoietic SH2 domain containing 33 0.009
 GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough 32 0.030
 LINC01000 long intergenic non-protein coding RNA 1000 32 0.026
 SNORD88A small nucleolar RNA, C/D box 88A 32 0.014
 CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 32 0.049
 KRT73 keratin 73, type II 32 0.034
 SDF4 stromal cell derived factor 4 31 0.012
 CD247 CD247 molecule 31 0.042
 TMSB4XP4 thymosin beta 4, X-linked pseudogene 4 31 0.026
 CD200R1 CD200 receptor 1 31 0.032
 CISH cytokine inducible SH2-containing protein 31 0.011
 MX2 MX dynamin-like GTPase 2 30 0.035
 MICALCL MICAL C-terminal like 30 0.026
 CD5 CD5 molecule 30 0.037
 C15orf54 chromosome 15 open reading frame 54 − 108 0.008
 RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) − 91 0.031
 LOC105370195 uncharacterized LOC105370195 − 89 0.012
 MYCT1 myc target 1 −67 0.011
 MS4A1 membrane-spanning 4-domains, subfamily A, member 1 −64 0.045
 LOC105377384 uncharacterized LOC105377384 −56 0.034
 OR2L1P olfactory receptor, family 2, subfamily L, member 1 pseudogene −55 0.006
 LOC105379818 uncharacterized LOC105379818 −51 0.021
 CD1C CD1c molecule −49 0.001
 LOC105369884 uncharacterized LOC105369884 −49 0.002
 LOC102724714 uncharacterized LOC102724714 −47 0.030
 RSU1 Ras suppressor protein 1 −47 0.010
 TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 −46 0.028
 SNORD42A small nucleolar RNA, C/D box 42A −45 0.026
 WDR11-AS1 WDR11 antisense RNA 1 − 43 0.025
 LINC00989 long intergenic non-protein coding RNA 989 −43 0.043
 CRYZ crystallin zeta −43 0.016
 DNM3 dynamin 3 −43 0.012
 LINC00266–1 long intergenic non-protein coding RNA 266–1 −42 0.021
 SLFN14 schlafen family member 14 −40 0.029
 HIST1H2BC histone cluster 1, H2bc −38 0.016
 GFI1B growth factor independent 1B transcription repressor −37 0.016
 PF4 platelet factor 4 −37 0.015
 PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A −36 0.041
 SENCR smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA −36 0.002
 LOC101928979 uncharacterized LOC101928979 −35 0.023
 MIR1321 microRNA 1321 −34 0.016
 CTTN cortactin −33 0.033
 GRB14 growth factor receptor bound protein 14 −32 0.008
 PCYT1B phosphate cytidylyltransferase 1, choline, beta −32 0.028
 P2RY1 purinergic receptor P2Y, G-protein coupled, 1 −32 0.011
 KCNQ5-IT1 KCNQ5 intronic transcript 1 −32 0.037
 FAM111B family with sequence similarity 111, member B −32 0.014
 GUSBP1 glucuronidase, beta pseudogene 1 −31 0.033
 LIMS1 LIM and senescent cell antigen-like domains 1 −31 0.016
Patients with nAMD
 OSBP2 oxysterol binding protein 2 151 0.002
 IGHV1OR21–1 immunoglobulin heavy variable 1/OR21–1 (non-functional) 106 0.013
 ANK1 ankyrin 1, erythrocytic 83 0.002
 PITHD1 PITH (C-Terminal Proteasome-Interacting Domain Of Thioredoxin-Like) Domain Containing 1 82 0.009
 MIR4644 microRNA 4644 64 0.027
 MARCH8 membrane associated ring finger 8 61 0.001
 PAGE2B P antigen family, member 2B 60 0.009
 TMOD1 tropomodulin 1 60 0.013
 HBD hemoglobin, delta 56 0.003
 LOC401127 WD repeat domain 5 pseudogene 51 0.018
 RHD Rh blood group, D antigen 48 0.036
 TRBV7–4 T cell receptor beta variable 7–4 (gene/pseudogene) 48 0.001
 USP32P1 ubiquitin specific peptidase 32 pseudogene 1 47 0.038
 FAM210B family with sequence similarity 210, member B 47 0.027
 BPGM 2,3-bisphosphoglycerate mutase 47 0.040
 FECH ferrochelatase 45 0.009
 LINC01291 long intergenic non-protein coding RNA 1291 44 < 0.001
 HBM hemoglobin, mu 43 0.015
 MMP8 matrix metallopeptidase 8 43 0.004
 DCAF12 DDB1 and CUL4 associated factor 12 41 0.044
 FAM46C family with sequence similarity 46, member C 40 0.043
 LTF lactotransferrin 39 0.001
 PGLYRP1 peptidoglycan recognition protein 1 37 0.007
 CAMP cathelicidin antimicrobial peptide 35 0.010
 SLC25A39 solute carrier family 25, member 39 34 0.010
 SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 34 0.013
 SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 32 0.009
 SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 31 0.001
 IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 31 0.002
 AHSP alpha hemoglobin stabilizing protein 31 0.015
 ALAS2 5-aminolevulinate synthase 2 30 0.001
 RNU4ATAC RNA, U4atac small nuclear (U12-dependent splicing) − 125 0.002
 SNORD3C small nucleolar RNA, C/D box 3C −66 0.028
 ADAM28 ADAM metallopeptidase domain 28 − 48 0.017
 RNU5E-1 RNA, U5E small nuclear 1 −42 0.044
 SNORD12C small nucleolar RNA, C/D box 12C −41 0.026
 FRG1JP FSHD region gene 1 family member J, pseudogene −37 0.005
 MIR1537 microRNA 1537 −36 0.025
 CD1C CD1c molecule −34 0.004
 SNAR-G2 small ILF3/NF90-associated RNA G2 − 34 0.018
 LOC105374775 uncharacterized LOC105374775 −31 0.033
Patients with PCV
 TRIM48 tripartite motif containing 48 146 0.040
 LOC105373103 uncharacterized LOC105373103 54 0.026
 TRAJ13 T cell receptor alpha joining 13 45 0.046
 SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 44 0.040
 IGKV1–12 immunoglobulin kappa variable 1–12 42 0.024
 LTF lactotransferrin 41 0.050
 TRAV8–4 T cell receptor alpha variable 8–4 40 0.041
 IGHG4 immunoglobulin heavy constant gamma 4 (G4 m marker) 37 0.021
 IGKV2D-24 immunoglobulin kappa variable 2D-24 (non-functional) 34 0.024
 SNORA71D small nucleolar RNA, H/ACA box 71D 34 0.013
 FAR2P3 fatty acyl-CoA reductase 2 pseudogene 3 30 0.011
 LOC101928215 uncharacterized LOC101928215 −81 0.001
 SNORD117 small nucleolar RNA, C/D box 117 − 76 0.017
 SNORD63 small nucleolar RNA, C/D box 63 −73 0.017
 SCARNA9L small Cajal body-specific RNA 9-like −63 0.028
 SNORD14E small nucleolar RNA, C/D box 14E −62 0.004
 SNORD59B small nucleolar RNA, C/D box 59B −61 0.032
 ZEB2 zinc finger E-box binding homeobox 2 −58 0.044
 LOC105370515 uncharacterized LOC105370515 −48 0.017
 H1F0 H1 histone family, member 0 −47 0.017
 USP12-AS1 USP12 antisense RNA 1 −47 0.023
 TRAJ56 T cell receptor alpha joining 56 −46 0.001
 CD1C CD1c molecule −42 0.001
 RNVU1–15 RNA, variant U1 small nuclear 15 −42 0.008
 LOC728093 putative POM121-like protein 1-like −41 0.045
 LOC105374775 uncharacterized LOC105374775 −40 0.010
 LOC105375566 uncharacterized LOC105375566 −39 0.035
 LOC101927770 uncharacterized LOC101927770 −36 0.030
 FLT3 fms-related tyrosine kinase 3 −35 0.011
 OR2L1P olfactory receptor, family 2, subfamily L, member 1 pseudogene −34 0.030
 LOC100272216 uncharacterized LOC100272216 −34 0.028
 MERTK MER proto-oncogene, tyrosine kinase −34 0.023
 MIR486–2 microRNA 486–2 −33 0.029
 NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta −33 0.046
 LOC105378488 uncharacterized LOC105378488 −33 0.017
 MIR3160–1 microRNA 3160–1 −32 0.004
 YPEL5 yippee like 5 −32 0.002
 NLRP3 NLR family, pyrin domain containing 3 −31 0.035
 SNORA7B small nucleolar RNA, H/ACA box 7B −31 0.045
 HIST1H2BN histone cluster 1, H2bn −31 0.018
 LOC101929516 uncharacterized LOC101929516 −30 0.049
  1. Abbreviations: FC Fold change, GA Geographic atrophy, nAMD Neovascular age-related macular degeneration, PCV Polypoidal choroidal vasculopathy