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Table 3 Enrichr-based Gene Ontology (GO) enrichment analysis of genes significantly increased or decreased in expression in peripheral blood mononuclear cells of patients with different clinical subtypes of late AMD. Listed are the three strongest in each category (ranked using the Enrichr computed combined score (CS) which multiplies log p-value to z-score; only CS > 5 were considered to only consider strong signals) within the three GO-terms: Biological Process (BP), Molecular Function (MF), and Cellular Component (CC)

From: The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration

Increased

Decreased

GO

Description

CS

GO

Description

CS

Patients with GA vs. Healthy controls

 BP

response to interferon-alpha

15.10

BP

positive regulation of memory T cell differentiation

14.05

 BP

positive regulation of autophagy of mitochondrion

13.71

BP

regulation of memory T cell differentiation

13.18

 BP

type I interferon signaling pathway

13.08

BP

positive regulation of T-helper 2 cell differentiation

13.16

 MF

urea transmembrane transporter activity

15.87

MF

NADPH binding

12.91

 MF

acetylcholine receptor regulator activity

15.48

MF

G-protein coupled nucleotide receptor activity

12.90

 MF

amide transmembrane transporter activity

12.40

MF

G-protein coupled purinergic nucleotide receptor activity

12.70

 CC

T cell receptor complex

10.27

CC

 CC

Cul4-RING E3 ubiquitin ligase complex

6.62

CC

 CC

CC

Patients with nAMD vs. Healthy controls

 BP

oxygen gas homeostasis

21.30

BP

lymphocyte activation involved in immune response

10.65

 BP

gas homeostasis

18.33

BP

T cell activation involved in immune response

8.71

 BP

regulation of cellular carbohydrate catabolic process

17.35

BP

 MF

urea transmembrane transporter activity

15.36

MF

peptidase activity, acting on L-amino acid peptides

5.27

 MF

iron ion transmembrane transporter activity

15.27

MF

 MF

sodium:bicarbonate symporter activity

13.78

MF

 CC

specific granule lumen

26.32

CC

 CC

tertiary granule lumen

25.98

CC

 CC

endocytic vesicle lumen

20.12

CC

Patients with PCV vs. Healthy controls

 BP

regulator of immune effector process

18.39

BP

negative regulation of acute inflammatory response

13.62

 BP

positive regulation of toll-like receptor 4 signaling pathway

18.14

BP

positive regulation of T-helper 2 cell differentiation

13.62

 BP

negative regulation by host of viral process

15.92

BP

regulation of T-helper 2 cell cytokine production

12.56

 MF

urea transmembrane transporter activity

18.92

MF

vascular endothelial growth factor-activated receptor activity

13.97

 MF

amide transmembrane transporter activity

14.94

MF

MAP kinase kinase kinase activity

11.30

 MF

signal recognition particle binding

13.89

MF

transmembrane receptor protein tyrosine kinase activity

9.35

 CC

endocytic vesicle lumen

11.94

CC

NLRP3 inflammasome complex

9.85

 CC

specific granule lumen

6.87

CC

nuclear euchromatin

9.33

 CC

tertiary granule lumen

6.77

CC

euchromatin

8.98

  1. Abbreviations: BP Biological process, CC Cellular component, CS Combined score, GA Geographic atrophy, GO Gene ontology, MF Molecular function, nAMD Neovascular age-related macular degeneration, PCV Polypoidal choroidal vasculopathy