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Table 3 Enrichr-based Gene Ontology (GO) enrichment analysis of genes significantly increased or decreased in expression in peripheral blood mononuclear cells of patients with different clinical subtypes of late AMD. Listed are the three strongest in each category (ranked using the Enrichr computed combined score (CS) which multiplies log p-value to z-score; only CS > 5 were considered to only consider strong signals) within the three GO-terms: Biological Process (BP), Molecular Function (MF), and Cellular Component (CC)

From: The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration

Increased Decreased
GO Description CS GO Description CS
Patients with GA vs. Healthy controls
 BP response to interferon-alpha 15.10 BP positive regulation of memory T cell differentiation 14.05
 BP positive regulation of autophagy of mitochondrion 13.71 BP regulation of memory T cell differentiation 13.18
 BP type I interferon signaling pathway 13.08 BP positive regulation of T-helper 2 cell differentiation 13.16
 MF urea transmembrane transporter activity 15.87 MF NADPH binding 12.91
 MF acetylcholine receptor regulator activity 15.48 MF G-protein coupled nucleotide receptor activity 12.90
 MF amide transmembrane transporter activity 12.40 MF G-protein coupled purinergic nucleotide receptor activity 12.70
 CC T cell receptor complex 10.27 CC
 CC Cul4-RING E3 ubiquitin ligase complex 6.62 CC
Patients with nAMD vs. Healthy controls
 BP oxygen gas homeostasis 21.30 BP lymphocyte activation involved in immune response 10.65
 BP gas homeostasis 18.33 BP T cell activation involved in immune response 8.71
 BP regulation of cellular carbohydrate catabolic process 17.35 BP
 MF urea transmembrane transporter activity 15.36 MF peptidase activity, acting on L-amino acid peptides 5.27
 MF iron ion transmembrane transporter activity 15.27 MF
 MF sodium:bicarbonate symporter activity 13.78 MF
 CC specific granule lumen 26.32 CC
 CC tertiary granule lumen 25.98 CC
 CC endocytic vesicle lumen 20.12 CC
Patients with PCV vs. Healthy controls
 BP regulator of immune effector process 18.39 BP negative regulation of acute inflammatory response 13.62
 BP positive regulation of toll-like receptor 4 signaling pathway 18.14 BP positive regulation of T-helper 2 cell differentiation 13.62
 BP negative regulation by host of viral process 15.92 BP regulation of T-helper 2 cell cytokine production 12.56
 MF urea transmembrane transporter activity 18.92 MF vascular endothelial growth factor-activated receptor activity 13.97
 MF amide transmembrane transporter activity 14.94 MF MAP kinase kinase kinase activity 11.30
 MF signal recognition particle binding 13.89 MF transmembrane receptor protein tyrosine kinase activity 9.35
 CC endocytic vesicle lumen 11.94 CC NLRP3 inflammasome complex 9.85
 CC specific granule lumen 6.87 CC nuclear euchromatin 9.33
 CC tertiary granule lumen 6.77 CC euchromatin 8.98
  1. Abbreviations: BP Biological process, CC Cellular component, CS Combined score, GA Geographic atrophy, GO Gene ontology, MF Molecular function, nAMD Neovascular age-related macular degeneration, PCV Polypoidal choroidal vasculopathy