Table 5 Enrichr-based Gene Ontology (GO) enrichment analysis of genes significantly increased or decreased in expression in peripheral blood mononuclear cells of patients with neovascular AMD with subretinal fibrosis compared to those without subretinal fibrosis. Listed are the three strongest in each category (ranked using the Enrichr computed combined score (CS) which multiplies log p-value to z-score; only CS > 5 were considered to only consider strong signals) within the three GO-terms: Biological Process (BP), Molecular Function (MF), and Cellular Component (CC)
Subretinal fibrosis present vs. Subretinal fibrosis absent | |||||
|---|---|---|---|---|---|
Increased | Decreased | ||||
GO | Description | CS | GO | Description | CS |
BP | mRNA splicing, via spliceosome | 12.17 | BP | negative regulation of interleukin-1 beta secretion | 6.71 |
BP | mRNA splice site selection | 12.17 | BP | endothelial cell migration | 6.65 |
BP | regulation of mRNA splicing, via spliceosome | 11.93 | BP | negative regulation of interleukin-1 secretion | 6.36 |
MF | ubiquitin-like protein ligase activity | 29.03 | MF | dipeptidyl-peptidase activity | 7.76 |
MF | RNA binding | 28.09 | MF | caspase binding | 7.07 |
MF | ubiquitin-specific protease binding | 27.92 | MF | – | – |
CC | nuclear speck | 21.62 | CC | invadopodium | 5.53 |
CC | nuclear body | 21.52 | CC | – | – |
CC | ribonucleoprotein granule | 14.72 | CC | – | – |