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Table 5 Enrichr-based Gene Ontology (GO) enrichment analysis of genes significantly increased or decreased in expression in peripheral blood mononuclear cells of patients with neovascular AMD with subretinal fibrosis compared to those without subretinal fibrosis. Listed are the three strongest in each category (ranked using the Enrichr computed combined score (CS) which multiplies log p-value to z-score; only CS > 5 were considered to only consider strong signals) within the three GO-terms: Biological Process (BP), Molecular Function (MF), and Cellular Component (CC)

From: The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration

Subretinal fibrosis present vs. Subretinal fibrosis absent
Increased Decreased
GO Description CS GO Description CS
BP mRNA splicing, via spliceosome 12.17 BP negative regulation of interleukin-1 beta secretion 6.71
BP mRNA splice site selection 12.17 BP endothelial cell migration 6.65
BP regulation of mRNA splicing, via spliceosome 11.93 BP negative regulation of interleukin-1 secretion 6.36
MF ubiquitin-like protein ligase activity 29.03 MF dipeptidyl-peptidase activity 7.76
MF RNA binding 28.09 MF caspase binding 7.07
MF ubiquitin-specific protease binding 27.92 MF
CC nuclear speck 21.62 CC invadopodium 5.53
CC nuclear body 21.52 CC
CC ribonucleoprotein granule 14.72 CC
  1. Abbreviations: BP Biological process, CC Cellular component, CS Combined score, GO Gene ontology, MF Molecular function