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Fig. 2 | Immunity & Ageing

Fig. 2

From: Age related human T cell subset evolution and senescence

Fig. 2

Age-related shift in T cell distribution and TSCM homeostasis. a The gating strategy of the T cell subsets populations TCM (CCR7 + CD45RO+), TEM (CCR7-CD45RO+), and TEF (CCR7-CD45RO-), which were gated from CD4 and CD8 T subsets; naïve T cells (CD28 + CD95-) and TSCM cells (CD28 + CD95+) were gated from the CCR7 + CD45RO- T cell subset according to the expression of CD28 and CD95. The curves and red arrow represent the gate to be copied to gate the expression of CD95 and CCR7 on CD4+ or CD8+ T cells. b Correlation and regression analysis of different T cell subsets and ages were calculated. The left represents the frequency, and the right represents the absolute number. The red points and bars represent the R-value and 95% confidence R-value of the regression equation. The P value to the right of the figure indicates the statistical significance of each subset, and the red box represents the frequency and absolute number of naïve, TSCM, TCM, TEM, and TEF, and the blue box represents the relationship between the expression of CD28- and CD95+ and age in the above subsets; c While the absolute numbers of CD4 and CD8 naïve and CD8 TSCM but not CD4 TSCM decrease with age, the ratio of CD4 TSCM to CD8 naïve and CD8 TSCM to naïve cells linearly increased with age

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