Fig. 3

Percentage of polyclonally distributed, shifted, restricted, and mono/oligoclonally expanded TR repertoire (a) and average percentages of TRBV perturbations (b).Legend: The complexity of individual TRBV CDR3 size distributions was determined by counting the number of distinct peaks within each TRBV subgroup to classify it into 4 categories: normal (≥7 peaks, Gaussian distribution), shifted (≥7 peaks, deviation from Gaussian distribution), restricted (< 7 peaks prominent deviation from Gaussian distribution), and mono/oligoclonal (one or two dominant peaks). For each individual, the proportions of TRBV subgroups with a CDR3 distribution belonging to each one of these categories were calculated. The reported significance was obtained comparing the within-patient proportions of pooled shifted, restricted and mono/oligoclonal vs. normal polyclonal TRBV subgroups in patients and HC. Average percentages of TRBV perturbations; each dot represents the global average perturbation of the TRBV repertoire in each subject (B). Displayed results were calculated in perinatally HIV-infected youths (pHIVy), in non-perinatally HIV-infected youths (npHIVy) and healthy controls (HC). Bars indicate median and IQR values