Fig. 7

Changes in clinical frailty index after challenge. At day 0 (post-vaccination but pre-challenge) and day 25 post-infection, clinical frailty indices were measured. The percent difference was calculated for each mouse that survived (25 dpi-0 dpi*100). A proportion of those with ≥3% change in each group was also calculated. Assigned frailty changes due to death are outlined in black. For statistical analysis, one-way ANOVA followed by Tukey’s multiple comparison test was used to compared to groups. Data is representative of 6–8 mice/group from 2 studies