Skip to main content


Fig. 3 | Immunity & Ageing

Fig. 3

From: Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

Fig. 3

Analysis of senescent markers and SASP mediators in stress-induced senescent SF. HSF in 14-day cultures subjected to stress-induced senescence with H2O2 or TNFα. a Change in CDKN2A and CDKN1A mRNA expression (n = 8). b Change in IL6, CXCL8, MMP3 and CCL2 mRNA expression (n = 12). c Change in IL-6 and IL-8 protein levels (n = 8). (*Wilcoxon test)

Back to article page