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Table 2 Bone parameters (fracture, BMD and TBS) according to quartiles of hs-CRP

From: “Inflammaging” and bone in the OsteoLaus cohort

 FirstSecondThirdFourthP-valueaP-value trend testbP-value adjustedc
N349347352335   
hs-CRP, median [IQR]0.5 [0.3–0.6]1.0 [0.9–1.3]2.0 [1.7–2.3]4.8 [3.6–7.2]   
Traumatic fracture (%)89 (25.5)79 (22.7)108 (30.6)82 (24.4)0.096 0.973
Major osteoporotic fracture (%)31 (8.8)43 (12.4)41 (11.6)31 (9.2)0.345 0.748
Incident 5 years fractures15/339 (4.4)24/339 (7.1)23/343 (5.2)17/325 (5.2)0.415 0.147
Spine average BMD0.901 ± 0.1540.916 ± 0.1660.928 ± 0.1580.957 ± 0.1690.001< 0.0010.625
Spine average T-score−1.32 ± 1.45− 1.17 ± 1.56− 1.1 ± 1.49− 0.78 ± 1.59< 0.001< 0.0010.717
Spine average TBS1.304 ± 0.1001.318 ± 0.1021.326 ± 0.0981.336 ± 0.1070.0006< 0.0010.231
Femoral neck BMD0.717 ± 0.1160.718 ± 0.1130.729 ± 0.1040.752 ± 0.1200.0002< 0.0010.781
Femoral neck T-score−1.18 ± 1.04−1.17 ± 1.02−1.08 ± 0.94−0.87 ± 0.180.0002< 0.0010.809
Femur total BMD0.835 ± 0.1140.845 ± 0.1160.858 ± 0.1150.879 ± 0.125< 0.001< 0.0010.895
Femur total T-score−0.88 ± 0.93−0.79 ± 0.94− 0.69 ± 0.93−0.51 ± 1.02< 0.001< 0.0010.823
  1. Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variablesa, p of trendb and after multiple adjustmentc (age, BMI, smoker, diabetes, alcohol, calcium, HRT)