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Table 4 Bone parameters (fracture, BMD and TBS) according to quartiles of interleukin 6

From: “Inflammaging” and bone in the OsteoLaus cohort

 FirstSecondThirdFourthP-valueaP-value trend testbP-value adjustedc
N333330326329   
Interleukin 6, median [IQR]0.41 [0.22–0.63]1.52 [1.19–1.87]3.84 [2.98–5.30]22.01 [12.33–61.31]   
Traumatic fracture (%)76 (22.8)99 (30.0)80 (24.5)91 (27.6)0.155 0.497
Major osteoporotic fracture (%)32 (9.61)39 (11.82)36 (11.04)35 (10.64)0.832 0.997
Incident fracture 5 years20/323 (6.2)12/320 (3.7)21/318 (6.6)22/323 (6.8)0.320 0.461
Spine average BMD0.921 ± 0.1680.932 ± 0.1640.933 ± 0.1550.915 ± 0.1680.4370.6960.375
Spine average T-score−1.13 ± 1.59−1.03 ± 1.54−1.01 ± 1.46−1.18 ± 1.580.4240.7070.367
Spine average TBS1.322 ± 0.1041.326 ± .01051.319 ± 0.1031.319 ± 0.0980.7730.5090.525
Femoral neck BMD0.724 ± 0.1130.727 ± 0.1140.741 ± 0.1120.727 ± 0.1990.2340.4240.391
Femoral neck T-score−1.13 ± 1.01−1.096 ± 1.02−0.97 ± 1.00−1.10 ± 1.070.2230.3970.361
Femur total BMD0.848 ± 0.1180.857 ± 0.1210.869 ± 0.1190.845 ± 0.1120.0460.9450.979
Femur total T-score−0.77 ± 0.96−0.69 ± 0.98− 0.59 ± 0.97−0.79 ± 0.920.0430.9130.987
  1. Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variablesa, p of trendb and after multiple adjustmentc (age, BMI, smoker, diabetes, alcohol, calcium, HRT)