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Table 5 Bone parameters (fracture, BMD and TBS) according to quartiles of tumour necrosis factor α

From: “Inflammaging” and bone in the OsteoLaus cohort

 

First

Second

Third

Fourth

P-valuea

P-value trend testb

P-value adjustedc

N

330

331

329

329

   

TNF-α, median [IQR]

1.74 [1.08–2.19]

3.71 [3.19–4.29]

6.18 [5.40–6.99]

12.23 [9.77–20.17]

   

Traumatic fracture (%)

84 (25.4)

95 (28.7)

86 (26.1)

81 (24.6)

0.662

 

0.500

Major osteoporotic fracture (%)

28 (8.4)

40 (12.0)

36 (10.9)

38 (11.5)

0.456

 

0.436

Incident fracture 5 years

23/325 (7.1)

13/320 (4.1)

13/320 (4.1)

26/320 (8.1)

0.054

 

0.678

Spine average BMD

0.930 ± 0.168

0.920 ± 0.156

0.920 ± 0.164

0.931 ± 0.168

0.730

0.893

0.315

Spine average T-score

−1.05 ± 1.58

−1.13 ± 1.47

−1.14 ± 1.55

−1.02 ± 1.57

0.697

0.814

0.342

Spine average TBS

1.326 ± 0.102

1.318 ± 0.099

1.316 ± 0.108

1.326 ± 0.101

0.451

0.981

0.816

Femoral neck BMD

0.738 ± 0.118

0.718 ± 0.114

0.729 ± 0.115

0.734 ± 0.111

0.152

0.937

0.755

Femoral neck T-score

−1.00 ± 1.06

−1.17 ± 1.02

−1.08 ± 1.03

− 1.04 ± 1.00

0.176

0.942

0.759

Femur total BMD

0.864 ± 0.121

0.842 ± 0.113

0.857 ± 0.117

0.856 ± 0.119

0.108

0.817

0.557

Femur total T-score

−0.64 ± 0.99

−0.82 ± 0.91

−0.69 ± 0.96

−0.70 ± 0.97

0.109

0.806

0.543

  1. Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variablesa, p of trendb and after multiple adjustmentc (age, BMI, smoker, diabetes, alcohol, calcium, HRT)