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Table 5 Bone parameters (fracture, BMD and TBS) according to quartiles of tumour necrosis factor α

From: “Inflammaging” and bone in the OsteoLaus cohort

 FirstSecondThirdFourthP-valueaP-value trend testbP-value adjustedc
N330331329329   
TNF-α, median [IQR]1.74 [1.08–2.19]3.71 [3.19–4.29]6.18 [5.40–6.99]12.23 [9.77–20.17]   
Traumatic fracture (%)84 (25.4)95 (28.7)86 (26.1)81 (24.6)0.662 0.500
Major osteoporotic fracture (%)28 (8.4)40 (12.0)36 (10.9)38 (11.5)0.456 0.436
Incident fracture 5 years23/325 (7.1)13/320 (4.1)13/320 (4.1)26/320 (8.1)0.054 0.678
Spine average BMD0.930 ± 0.1680.920 ± 0.1560.920 ± 0.1640.931 ± 0.1680.7300.8930.315
Spine average T-score−1.05 ± 1.58−1.13 ± 1.47−1.14 ± 1.55−1.02 ± 1.570.6970.8140.342
Spine average TBS1.326 ± 0.1021.318 ± 0.0991.316 ± 0.1081.326 ± 0.1010.4510.9810.816
Femoral neck BMD0.738 ± 0.1180.718 ± 0.1140.729 ± 0.1150.734 ± 0.1110.1520.9370.755
Femoral neck T-score−1.00 ± 1.06−1.17 ± 1.02−1.08 ± 1.03− 1.04 ± 1.000.1760.9420.759
Femur total BMD0.864 ± 0.1210.842 ± 0.1130.857 ± 0.1170.856 ± 0.1190.1080.8170.557
Femur total T-score−0.64 ± 0.99−0.82 ± 0.91−0.69 ± 0.96−0.70 ± 0.970.1090.8060.543
  1. Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variablesa, p of trendb and after multiple adjustmentc (age, BMI, smoker, diabetes, alcohol, calcium, HRT)