TY - JOUR AU - Edelman, Robert AU - Deming, Meagan E. AU - Toapanta, Franklin R. AU - Heuser, Mark D. AU - Chrisley, Lisa AU - Barnes, Robin S. AU - Wasserman, Steven S. AU - Blackwelder, William C. AU - Handwerger, Barry S. AU - Pasetti, Marcela AU - Siddiqui, Khan M. AU - Sztein, Marcelo B. PY - 2020 DA - 2020/04/28 TI - The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route JO - Immunity & Ageing SP - 9 VL - 17 IS - 1 AB - Reduced response to hepatitis B vaccines is associated with aging, confounding and comorbid conditions, as well as inadvertent subcutaneous (SC) inoculation. We hypothesized that the antibody and T cell-mediated immune responses (T-CMI) of elderly adults to a vaccine intended for intramuscular (IM) administration would be attenuated when deposited into SC fat, independent of confounding conditions. SN - 1742-4933 UR - https://doi.org/10.1186/s12979-020-00179-9 DO - 10.1186/s12979-020-00179-9 ID - Edelman2020 ER -