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Table 2 Baseline Volunteer Characteristics for Senior and Junior cohorts

From: The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route

Characteristic

SENIOR IM

SENIOR SC

JUNIOR

Number (Percent) Male

13 (50%)

11 (42%)

6 (42%)

Number (Percent) White

25 (96%)

24 (92%)

7 (50%)

Number (Percent) African-American

1 (4%)

2 (8%)

4 (26%)

Median age [range]

73 [65–81]

72 [65–80]

26 [21–34]

Age 65–74 (percent)

20 (77%)

19 (73%)

n/a

Age 75–81 (percent)

6 (23%)

7 (27%)

n/a

Smoker (< 10 cigarettes per day)

0

0

1 (7%)

Median years of education [range]

12 [4–16]

12 [10–18]

16 [14–18]

Alcohol (> 1 can beer, 1 glass wine, or 1 oz. liqueur daily).

0

0

0

Previous influenza or pneumococcal immunization

25 (96%)

25 (96%)

0

Median number of medications [range]

4 [0–8]

3 [0–9]

1 [0–4]

Use of supplemental vitamins

18 (69%)

17 (65%)

5 (36%)

Median co-morbid conditions [range]*

3 [0–7]

3 [0–7]

Not done

Median weight (kg) [range]

79.5 [55–110]

79.5 [53–114]

Median Body Mass Index [range]**

27.7 [22.3–38.6]

29.0 [20.0–41.9]

Median body percentage fat [range]

37.1 [24.5–49.1]

36.9 [20.9–51.4]

Median Charlson Index [range] ***

0 [0–3]

0 [0–3]

Median Mini-Mental Status Exam score+

29 [23–30]

30 [25–30]

Median OARS score [range]#

0 [0–2]

0 [0–0]

Geriatric Depression Scale scores##

0 [0–2]

0 [0–2]

  1. Seniors were randomized to receive the Hepatitis B vaccine by intramuscular (IM) or subcutaneous (SC) administration. Baseline characteristics were similar between Senior IM and SC administration groups. (*) Based on 12 common medical conditions; none = 0, maximum =12. (**) BMI “Normal” =18.5–24.9; “overweight” = 25.1–29.9; “obese” grade 1 = 30–34.9, grade 2 = 35–39.9; grade 3 ≥ 40 [29]. (***) Prognostic 10-year survival for individuals with multiple comorbidities: 0 = 99%; 2 = 90% [30]. (+) Measure of cognitive impairment. Score 24–30 indicates no cognitive impairment [31]. (#) Older Americans Resources and Services, a measure of functional status. Score < 3 = no assistance required for daily activities [32]. (##) Any one symptom of depression; maximum depression score = 15 [33]. n/a = not applicable