Table 2 For young control samples, the GO biological processes that were most significantly associated with HERV-K (HML-2) provirus 1q22 expression, ordered by p-value. Enrichment score for each GO biological process is determined through GSEA, as shown in Fig. 2. Set size refers to the total number of the studied genes associated to each process, while gene ratio is the number of those genes that strongly correlated with 1q22 expression. No significantly enriched GO terms were directly involved in neutrophil function in the young control samples
ID | Description | p-value | Adjusted p-value | FDR (q-value) | Enrichment | Gene ratio | Set size |
|---|---|---|---|---|---|---|---|
GO:0006325 | chromatin organization | 1.88E-05 | 8.19E-03 | 7.40E-03 | −0.273 | 40% | 475 |
GO:0060337 | type I interferon signaling pathway | 2.03E-05 | 8.19E-03 | 7.40E-03 | 0.491 | 58% | 50 |
GO:0071357 | cellular response to type I interferon | 2.03E-05 | 8.19E-03 | 7.40E-03 | 0.491 | 58% | 50 |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 2.06E-05 | 8.19E-03 | 7.40E-03 | 0.441 | 42% | 100 |
GO:0098542 | defense response to other organism | 2.10E-05 | 8.19E-03 | 7.40E-03 | 0.324 | 39% | 244 |
GO:0006954 | inflammatory response | 2.12E-05 | 8.19E-03 | 7.40E-03 | 0.280 | 38% | 348 |
GO:0019221 | cytokine-mediated signaling pathway | 2.13E-05 | 8.19E-03 | 7.40E-03 | 0.299 | 32% | 425 |
GO:0032732 | positive regulation of interleukin-1 production | 4.05E-05 | 1.10E-02 | 9.94E-03 | 0.584 | 44% | 27 |
GO:0050702 | interleukin-1 beta secretion | 4.06E-05 | 1.10E-02 | 9.94E-03 | 0.561 | 48% | 29 |
GO:0070126 | mitochondrial translational termination | 4.10E-05 | 1.10E-02 | 9.94E-03 | 0.439 | 46% | 70 |
GO:0042752 | regulation of circadian rhythm | 5.87E-05 | 1.38E-02 | 1.24E-02 | −0.453 | 49% | 63 |
GO:0006415 | translational termination | 6.15E-05 | 1.38E-02 | 1.24E-02 | 0.412 | 45% | 80 |
GO:0071356 | cellular response to tumor necrosis factor | 1.04E-04 | 1.99E-02 | 1.80E-02 | 0.347 | 35% | 146 |
GO:0034612 | response to tumor necrosis factor | 1.04E-04 | 1.99E-02 | 1.80E-02 | 0.329 | 33% | 160 |
GO:0050701 | interleukin-1 secretion | 1.22E-04 | 2.18E-02 | 1.97E-02 | 0.545 | 47% | 32 |
GO:0032613 | interleukin-10 production | 1.62E-04 | 2.59E-02 | 2.34E-02 | 0.523 | 45% | 33 |
GO:0070125 | mitochondrial translational elongation | 1.64E-04 | 2.59E-02 | 2.34E-02 | 0.429 | 46% | 68 |
GO:0034340 | response to type I interferon | 1.83E-04 | 2.73E-02 | 2.46E-02 | 0.460 | 54% | 54 |
GO:0032543 | mitochondrial translation | 2.06E-04 | 2.76E-02 | 2.49E-02 | 0.365 | 39% | 101 |
GO:0007507 | heart development | 2.11E-04 | 2.76E-02 | 2.49E-02 | −0.289 | 33% | 240 |