Immunity & Ageing

Table 2 Correlations between CD4⁺ T cell subsets, expression of PD-1 and IL-7Rα within CD4⁺ T cell subsets in the BM and BMI

From: The impact of body mass index on adaptive immune cells in the human bone marrow

	All		CMV⁻		CMV⁺
	r_s	p value	r_s	p value	r_s	p value
CD4⁺T cells (of CD3⁺)	0.36	0.02	0.38	0.01	0.12	0.59
CCR7⁺CD45RA⁺(CD4⁺T_N)	0.45	0.002	0.23	0.35	0.51	0.02
CCR7⁺CD45RA⁻(CD4⁺T_CM)	0.34	0.03	− 0.18	0.46	0.59	0.01
CCR7⁻CD45RA⁻(CD4⁺T_EM)	− 0.03	0.87	− 0.15	0.53	− 0.58	0.01
CCR7⁻CD45RA⁺(CD4⁺_TEMRA)	0.34	0.05	0.43	0.04	0.41	0.05
CD4⁺CD28⁻	− 0.02	0.91	− 0.16	0.50	− 0.01	0.96
CD4⁺CD57⁺	0.00	1.00	0.16	0.42	0.27	0.91
CD4⁺PD-1⁺	−0.20	0.73	− 0.41	0.04	− 0.39	0.08
CD4⁺IL-7Rα⁺	0.43	0.03	0.37	0.12	0.03	0.91
PD-1⁺CD4⁺T_CM	−0.36	0.02	− 0.21	0.39	− 0.22	0.34
PD-1⁺CD4⁺T_EM	−0.39	0.01	−0.49	0.03	−0.16	0.48
CD57⁺CD4⁺T_EM	−0.19	0.22	−0.02	0.93	0.14	0.55
PD-1⁺CD4⁺T_EMRA	−0.33	0.10	−0.19	0.44	0.01	0.97
CD57⁺CD4⁺T_EMRA	−0.03	0.85	−0.01	0.98	0.19	0.39

Spearman correlation coefficients (r_s) and p values for CMV⁻ and CMV⁺ persons and for the whole cohort are shown. p < 0.05 was considered significant. For all subpopulations, N_CMV⁻ = 20, N_CMV⁺ = 19, N_all = 39. Detailed gating strategy used to define the populations are shown in Fig. 3
Statistically significant values are shown in bold

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