Table 3 Adjusted hazard ratios of time to treatment failure
Variable | Aged between 60 and 79 years | Aged more than 80 years | ||||
|---|---|---|---|---|---|---|
HR | (95%CI) | p-value | HR | (95%CI) | p-value | |
Frontline treatment | ||||||
R-CHOP | 1 | < 0.0001 | 1 | < 0.0001 | ||
R-CVP | 1.64 | (1.43–1.88) | 1.52 | (1.22–1.91) | ||
CHOP | 4.49 | (3.63–5.57) | 3.58 | (2.21–5.81) | ||
CVP | 6.70 | (5.08–8.82) | 3.00 | (2.11–4.29) | ||
Gender | ||||||
male | 1 | 0.0271 | 1 | 0.4817 | ||
female | 0.88 | (0.79–0.99) | 0.93 | (0.75–1.14) | ||
Age | 1.01 | (1.00–1.02) | 0.1303 | 1.03 | (1.00–1.05) | 0.0915 |
Ann Arbor stage | ||||||
I | 1 | < 0.0001 | 1 | < 0.0001 | ||
II | 1.40 | (1.14–1.72) | 1.22 | (0.85–1.74) | ||
III | 2.24 | (1.83–2.74) | 1.57 | (1.12–2.20) | ||
IV | 3.12 | (2.58–3.77) | 2.24 | (1.62–3.09) | ||
Radiotherapy | ||||||
No | 1 | 0.6740 | 1 | 0.1561 | ||
Yes | 1.03 | (0.90–1.19) | 0.82 | (0.62–1.08) | ||
Carlson comorbidity index | ||||||
0 | 1 | 0.0008 | 1 | 0.7690 | ||
1 | 1.07 | (0.93–1.23) | 1.03 | (0.80–1.34) | ||
2+ | 1.27 | (1.12–1.45) | 1.09 | (0.85–1.40) | ||
Practice setting | ||||||
medical center | 1 | 0.3868 | 1 | 0.5453 | ||
others | 1.05 | (0.94–1.18) | 0.94 | (0.76–1.16) | ||