| Variable | Aged between 60 and 79 years | Aged more than 80 years |
|---|
| HR | (95%CI) | p-value | HR | (95%CI) | p-value |
|---|
| Frontline treatment |
| R-CHOP | 1 | | < 0.0001 | 1 | | < 0.0001 |
| R-CVP | 1.64 | (1.43–1.88) | | 1.52 | (1.22–1.91) | |
| CHOP | 4.49 | (3.63–5.57) | | 3.58 | (2.21–5.81) | |
| CVP | 6.70 | (5.08–8.82) | | 3.00 | (2.11–4.29) | |
| Gender |
| male | 1 | | 0.0271 | 1 | | 0.4817 |
| female | 0.88 | (0.79–0.99) | | 0.93 | (0.75–1.14) | |
| Age | 1.01 | (1.00–1.02) | 0.1303 | 1.03 | (1.00–1.05) | 0.0915 |
| Ann Arbor stage |
| I | 1 | | < 0.0001 | 1 | | < 0.0001 |
| II | 1.40 | (1.14–1.72) | | 1.22 | (0.85–1.74) | |
| III | 2.24 | (1.83–2.74) | | 1.57 | (1.12–2.20) | |
| IV | 3.12 | (2.58–3.77) | | 2.24 | (1.62–3.09) | |
| Radiotherapy |
| No | 1 | | 0.6740 | 1 | | 0.1561 |
| Yes | 1.03 | (0.90–1.19) | | 0.82 | (0.62–1.08) | |
| Carlson comorbidity index |
| 0 | 1 | | 0.0008 | 1 | | 0.7690 |
| 1 | 1.07 | (0.93–1.23) | | 1.03 | (0.80–1.34) | |
| 2+ | 1.27 | (1.12–1.45) | | 1.09 | (0.85–1.40) | |
| Practice setting |
| medical center | 1 | | 0.3868 | 1 | | 0.5453 |
| others | 1.05 | (0.94–1.18) | | 0.94 | (0.76–1.16) | |
