TY - JOUR AU - Gavazzi, G. AU - Krause, K. H. PY - 2002 DA - 2002// TI - Ageing and infection JO - Lancet Infect Dis VL - 2 UR - https://doi.org/10.1016/S1473-3099(02)00437-1 DO - 10.1016/S1473-3099(02)00437-1 ID - Gavazzi2002 ER - TY - JOUR AU - Gross, P. A. AU - Hermogenes, A. W. AU - Sacks, H. S. AU - Lau, J. AU - Levandowski, R. A. PY - 1995 DA - 1995// TI - The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature JO - Ann Intern Med VL - 123 UR - https://doi.org/10.7326/0003-4819-123-7-199510010-00008 DO - 10.7326/0003-4819-123-7-199510010-00008 ID - Gross1995 ER - TY - JOUR AU - Siegrist, C. A. AU - Aspinall, R. PY - 2009 DA - 2009// TI - B-cell responses to vaccination at the extremes of age JO - Nat Rev Immunol VL - 9 UR - https://doi.org/10.1038/nri2508 DO - 10.1038/nri2508 ID - Siegrist2009 ER - TY - JOUR AU - Goronzy, J. J. AU - Weyand, C. M. PY - 2017 DA - 2017// TI - Successful and maladaptive T cell aging JO - Immunity VL - 46 UR - https://doi.org/10.1016/j.immuni.2017.03.010 DO - 10.1016/j.immuni.2017.03.010 ID - Goronzy2017 ER - TY - JOUR AU - Frasca, D. AU - Blomberg, B. B. PY - 2009 DA - 2009// TI - Effects of aging on B cell function JO - Curr Opin Immunol VL - 21 UR - https://doi.org/10.1016/j.coi.2009.06.001 DO - 10.1016/j.coi.2009.06.001 ID - Frasca2009 ER - TY - JOUR AU - Linton, P. J. AU - Haynes, L. AU - Klinman, N. R. AU - Swain, S. L. PY - 1996 DA - 1996// TI - Antigen-independent changes in naive CD4 T cells with aging JO - J Exp Med VL - 184 UR - https://doi.org/10.1084/jem.184.5.1891 DO - 10.1084/jem.184.5.1891 ID - Linton1996 ER - TY - JOUR AU - Weiskopf, D. AU - Weinberger, B. AU - Grubeck-Loebenstein, B. PY - 2009 DA - 2009// TI - The aging of the immune system JO - Transpl Int VL - 22 UR - https://doi.org/10.1111/j.1432-2277.2009.00927.x DO - 10.1111/j.1432-2277.2009.00927.x ID - Weiskopf2009 ER - TY - JOUR AU - Naylor, K. AU - Li, G. AU - Vallejo, A. N. AU - Lee, W. W. AU - Koetz, K. AU - Bryl, E. AU - Witkowski, J. AU - Fulbright, J. AU - Weyand, C. M. AU - Goronzy, J. J. PY - 2005 DA - 2005// TI - The influence of age on T cell generation and TCR diversity JO - J Immunol VL - 174 UR - https://doi.org/10.4049/jimmunol.174.11.7446 DO - 10.4049/jimmunol.174.11.7446 ID - Naylor2005 ER - TY - JOUR AU - Hu, A. AU - Ehleiter, D. AU - Ben-Yehuda, A. AU - Schwab, R. AU - Russo, C. AU - Szabo, P. AU - Weksler, M. E. PY - 1993 DA - 1993// TI - Effect of age on the expressed B cell repertoire: role of B cell subsets JO - Int Immunol VL - 5 UR - https://doi.org/10.1093/intimm/5.9.1035 DO - 10.1093/intimm/5.9.1035 ID - Hu1993 ER - TY - JOUR AU - Plowden, J. AU - Renshaw-Hoelscher, M. AU - Engleman, C. AU - Katz, J. AU - Sambhara, S. PY - 2004 DA - 2004// TI - Innate immunity in aging: impact on macrophage function JO - Aging Cell VL - 3 UR - https://doi.org/10.1111/j.1474-9728.2004.00102.x DO - 10.1111/j.1474-9728.2004.00102.x ID - Plowden2004 ER - TY - JOUR AU - Nikolich-Žugich, J. AU - Li, G. AU - Uhrlaub, J. L. AU - Renkema, K. R. AU - Smithey, M. J. PY - 2012 DA - 2012// TI - Age-related changes in CD8 T cell homeostasis and immunity to infection JO - Semin Immunol VL - 24 UR - https://doi.org/10.1016/j.smim.2012.04.009 DO - 10.1016/j.smim.2012.04.009 ID - Nikolich-Žugich2012 ER - TY - JOUR AU - Hearps, A. C. AU - Martin, G. E. AU - Angelovich, T. A. AU - Cheng, W. J. AU - Maisa, A. AU - Landay, A. L. AU - Jaworowski, A. AU - Crowe, S. M. PY - 2012 DA - 2012// TI - Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function JO - Aging Cell VL - 11 UR - https://doi.org/10.1111/j.1474-9726.2012.00851.x DO - 10.1111/j.1474-9726.2012.00851.x ID - Hearps2012 ER - TY - JOUR AU - Gibson, K. L. AU - Wu, Y. C. AU - Barnett, Y. AU - Duggan, O. AU - Vaughan, R. AU - Kondeatis, E. AU - Nilsson, B. O. AU - Wikby, A. AU - Kipling, D. AU - Dunn-Walters, D. K. PY - 2009 DA - 2009// TI - B-cell diversity decreases in old age and is correlated with poor health status JO - Aging Cell VL - 8 UR - https://doi.org/10.1111/j.1474-9726.2008.00443.x DO - 10.1111/j.1474-9726.2008.00443.x ID - Gibson2009 ER - TY - CHAP AU - Dunn-Walters, D. K. AU - O’Hare, J. S. ED - Fulop, T. ED - Franceschi, C. ED - Hirokawa, K. ED - Pawelec, G. PY - 2019 DA - 2019// TI - Older Human B Cells and Antibodies BT - Handbook of Immunosenescence: Basic Understanding and Clinical Implications PB - Springer International Publishing CY - Cham UR - https://doi.org/10.1007/978-3-319-99375-1_21 DO - 10.1007/978-3-319-99375-1_21 ID - Dunn-Walters2019 ER - TY - JOUR AU - Frasca, D. AU - Blomberg, B. B. PY - 2011 DA - 2011// TI - Aging affects human B cell responses JO - J Clin Immunol VL - 31 UR - https://doi.org/10.1007/s10875-010-9501-7 DO - 10.1007/s10875-010-9501-7 ID - Frasca2011 ER - TY - JOUR AU - Goenka, R. AU - Scholz, J. L. AU - Naradikian, M. S. AU - Cancro, M. P. PY - 2014 DA - 2014// TI - Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics JO - Exp Gerontol VL - 54 UR - https://doi.org/10.1016/j.exger.2013.12.013 DO - 10.1016/j.exger.2013.12.013 ID - Goenka2014 ER - TY - JOUR AU - Britanova, O. V. AU - Putintseva, E. V. AU - Shugay, M. AU - Merzlyak, E. M. AU - Turchaninova, M. A. AU - Staroverov, D. B. AU - Bolotin, D. A. AU - Lukyanov, S. AU - Bogdanova, E. A. AU - Mamedov, I. Z. PY - 2014 DA - 2014// TI - Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling JO - J Immunol VL - 192 UR - https://doi.org/10.4049/jimmunol.1302064 DO - 10.4049/jimmunol.1302064 ID - Britanova2014 ER - TY - JOUR AU - Palmer, S. AU - Albergante, L. AU - Blackburn, C. C. AU - Newman, T. J. PY - 2018 DA - 2018// TI - Thymic involution and rising disease incidence with age JO - Proc Natl Acad Sci U S A VL - 115 UR - https://doi.org/10.1073/pnas.1714478115 DO - 10.1073/pnas.1714478115 ID - Palmer2018 ER - TY - JOUR AU - Vaziri, H. AU - Dragowska, W. AU - Allsopp, R. C. AU - Thomas, T. E. AU - Harley, C. B. AU - Lansdorp, P. M. PY - 1994 DA - 1994// TI - Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age JO - Proc Natl Acad Sci U S A VL - 91 UR - https://doi.org/10.1073/pnas.91.21.9857 DO - 10.1073/pnas.91.21.9857 ID - Vaziri1994 ER - TY - JOUR AU - Pang, W. W. AU - Price, E. A. AU - Sahoo, D. AU - Beerman, I. AU - Maloney, W. J. AU - Rossi, D. J. AU - Schrier, S. L. AU - Weissman, I. L. PY - 2011 DA - 2011// TI - Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1116110108 DO - 10.1073/pnas.1116110108 ID - Pang2011 ER - TY - JOUR AU - Geiger, H. AU - Haan, G. AU - Florian, M. C. PY - 2013 DA - 2013// TI - The ageing haematopoietic stem cell compartment JO - Nat Rev Immunol VL - 13 UR - https://doi.org/10.1038/nri3433 DO - 10.1038/nri3433 ID - Geiger2013 ER - TY - JOUR AU - Herrero, C. AU - Sebastián, C. AU - Marqués, L. AU - Comalada, M. AU - Xaus, J. AU - Valledor, A. F. AU - Lloberas, J. AU - Celada, A. PY - 2002 DA - 2002// TI - Immunosenescence of macrophages: reduced MHC class II gene expression JO - Exp Gerontol VL - 37 UR - https://doi.org/10.1016/S0531-5565(01)00205-4 DO - 10.1016/S0531-5565(01)00205-4 ID - Herrero2002 ER - TY - JOUR AU - Linton, P. J. AU - Thoman, M. L. PY - 2014 DA - 2014// TI - Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart JO - Immunol Lett VL - 162 UR - https://doi.org/10.1016/j.imlet.2014.06.017 DO - 10.1016/j.imlet.2014.06.017 ID - Linton2014 ER - TY - JOUR AU - Shaw, A. C. AU - Goldstein, D. R. AU - Montgomery, R. R. PY - 2013 DA - 2013// TI - Age-dependent dysregulation of innate immunity JO - Nat Rev Immunol VL - 13 UR - https://doi.org/10.1038/nri3547 DO - 10.1038/nri3547 ID - Shaw2013 ER - TY - JOUR AU - Howard, W. A. AU - Gibson, K. L. AU - Dunn-Walters, D. K. PY - 2006 DA - 2006// TI - Antibody quality in old age JO - Rejuvenation Res VL - 9 UR - https://doi.org/10.1089/rej.2006.9.117 DO - 10.1089/rej.2006.9.117 ID - Howard2006 ER - TY - JOUR AU - Dunn-Walters, D. K. AU - Banerjee, M. AU - Mehr, R. PY - 2003 DA - 2003// TI - Effects of age on antibody affinity maturation JO - Biochem Soc Trans VL - 31 UR - https://doi.org/10.1042/bst0310447 DO - 10.1042/bst0310447 ID - Dunn-Walters2003 ER - TY - JOUR AU - Nicoletti, C. AU - Yang, X. AU - Cerny, J. PY - 1993 DA - 1993// TI - Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae JO - J Immunol VL - 150 ID - Nicoletti1993 ER - TY - JOUR AU - Bovbjerg, D. H. AU - Kim, Y. T. AU - Schwab, R. AU - Schmitt, K. AU - DeBlasio, T. PY - 1991 DA - 1991// TI - Weksler ME: "cross-wiring" of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigen JO - Cell Immunol VL - 135 UR - https://doi.org/10.1016/0008-8749(91)90294-L DO - 10.1016/0008-8749(91)90294-L ID - Bovbjerg1991 ER - TY - JOUR AU - Zhao, K. S. AU - Wang, Y. F. AU - Guéret, R. AU - Weksler, M. E. PY - 1995 DA - 1995// TI - Dysregulation of the humoral immune response in old mice JO - Int Immunol VL - 7 UR - https://doi.org/10.1093/intimm/7.6.929 DO - 10.1093/intimm/7.6.929 ID - Zhao1995 ER - TY - JOUR AU - Weksler, M. E. PY - 2000 DA - 2000// TI - Changes in the B-cell repertoire with age JO - Vaccine VL - 18 UR - https://doi.org/10.1016/S0264-410X(99)00497-1 DO - 10.1016/S0264-410X(99)00497-1 ID - Weksler2000 ER - TY - JOUR AU - Rowley, M. J. AU - Buchanan, H. AU - Mackay, I. R. PY - 1968 DA - 1968// TI - Reciprocal change with age in antibody to extrinsic and intrinsic antigens JO - Lancet VL - 2 UR - https://doi.org/10.1016/S0140-6736(68)92893-6 DO - 10.1016/S0140-6736(68)92893-6 ID - Rowley1968 ER - TY - JOUR AU - Rowe, M. AU - Melnick, J. AU - Gerwien, R. AU - Legutki, J. B. AU - Pfeilsticker, J. AU - Tarasow, T. M. AU - Sykes, K. F. PY - 2017 DA - 2017// TI - An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors JO - PLoS Negl Trop Dis VL - 11 UR - https://doi.org/10.1371/journal.pntd.0005882 DO - 10.1371/journal.pntd.0005882 ID - Rowe2017 ER - TY - STD TI - NLM format citation: Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D. Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. Aging Cell. 2019;18(6):e13017. https://doi.org/10.1111/acel.13017. Epub 2019 Aug 24. PMID: 31444995; PMCID: PMC6826144. ID - ref33 ER - TY - JOUR AU - Ganna, A. AU - Ingelsson, E. PY - 2015 DA - 2015// TI - 5 year mortality predictors in 498,103 UK biobank participants: a prospective population-based study JO - Lancet VL - 386 UR - https://doi.org/10.1016/S0140-6736(15)60175-1 DO - 10.1016/S0140-6736(15)60175-1 ID - Ganna2015 ER - TY - JOUR AU - Needham, B. L. AU - Rehkopf, D. AU - Adler, N. AU - Gregorich, S. AU - Lin, J. AU - Blackburn, E. H. AU - Epel, E. S. PY - 2015 DA - 2015// TI - Leukocyte telomere length and mortality in the National Health and nutrition examination survey, 1999-2002 JO - Epidemiology VL - 26 UR - https://doi.org/10.1097/EDE.0000000000000299 DO - 10.1097/EDE.0000000000000299 ID - Needham2015 ER - TY - JOUR AU - Chen, B. H. AU - Marioni, R. E. AU - Colicino, E. AU - Peters, M. J. AU - Ward-Caviness, C. K. AU - Tsai, P. C. AU - Roetker, N. S. AU - Just, A. C. AU - Demerath, E. W. AU - Guan, W. PY - 2016 DA - 2016// TI - DNA methylation-based measures of biological age: meta-analysis predicting time to death JO - Aging (Albany NY) VL - 8 UR - https://doi.org/10.18632/aging.101020 DO - 10.18632/aging.101020 ID - Chen2016 ER - TY - JOUR AU - Marioni, R. E. AU - Shah, S. AU - McRae, A. F. AU - Chen, B. H. AU - Colicino, E. AU - Harris, S. E. AU - Gibson, J. AU - Henders, A. K. AU - Redmond, P. AU - Cox, S. R. PY - 2015 DA - 2015// TI - DNA methylation age of blood predicts all-cause mortality in later life JO - Genome Biol VL - 16 UR - https://doi.org/10.1186/s13059-015-0584-6 DO - 10.1186/s13059-015-0584-6 ID - Marioni2015 ER - TY - JOUR AU - Varadhan, R. AU - Yao, W. AU - Matteini, A. AU - Beamer, B. A. AU - Xue, Q. L. AU - Yang, H. AU - Manwani, B. AU - Reiner, A. AU - Jenny, N. AU - Parekh, N. PY - 2014 DA - 2014// TI - Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults JO - J Gerontol A Biol Sci Med Sci VL - 69 UR - https://doi.org/10.1093/gerona/glt023 DO - 10.1093/gerona/glt023 ID - Varadhan2014 ER - TY - JOUR AU - Ridker, P. M. AU - Everett, B. M. AU - Thuren, T. AU - MacFadyen, J. G. AU - Chang, W. H. AU - Ballantyne, C. AU - Fonseca, F. AU - Nicolau, J. AU - Koenig, W. AU - Anker, S. D. PY - 2017 DA - 2017// TI - Antiinflammatory therapy with Canakinumab for atherosclerotic disease JO - N Engl J Med VL - 377 UR - https://doi.org/10.1056/NEJMoa1707914 DO - 10.1056/NEJMoa1707914 ID - Ridker2017 ER - TY - JOUR AU - Alpert, A. AU - Pickman, Y. AU - Leipold, M. AU - Rosenberg-Hasson, Y. AU - Ji, X. AU - Gaujoux, R. AU - Rabani, H. AU - Starosvetsky, E. AU - Kveler, K. AU - Schaffert, S. PY - 2019 DA - 2019// TI - A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring JO - Nat Med VL - 25 UR - https://doi.org/10.1038/s41591-019-0381-y DO - 10.1038/s41591-019-0381-y ID - Alpert2019 ER - TY - JOUR AU - Earls, J. C. AU - Rappaport, N. AU - Heath, L. AU - Wilmanski, T. AU - Magis, A. T. AU - Schork, N. J. AU - Omenn, G. S. AU - Lovejoy, J. AU - Hood, L. AU - Price, N. D. PY - 2019 DA - 2019// TI - Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals JO - J Gerontol A Biol Sci Med Sci VL - 74 UR - https://doi.org/10.1093/gerona/glz220 DO - 10.1093/gerona/glz220 ID - Earls2019 ER - TY - JOUR AU - Zou, H. AU - Hastie, T. PY - 2005 DA - 2005// TI - Regularization and variable selection via the elastic net JO - J R Stat Soc Ser B (Statistical Methodology) VL - 67 UR - https://doi.org/10.1111/j.1467-9868.2005.00503.x DO - 10.1111/j.1467-9868.2005.00503.x ID - Zou2005 ER - TY - JOUR AU - Corper, A. L. AU - Sohi, M. K. AU - Bonagura, V. R. AU - Steinitz, M. AU - Jefferis, R. AU - Feinstein, A. AU - Beale, D. AU - Taussig, M. J. AU - Sutton, B. J. PY - 1997 DA - 1997// TI - Structure of human IgM rheumatoid factor fab bound to its autoantigen IgG fc reveals a novel topology of antibody-antigen interaction JO - Nat Struct Biol VL - 4 UR - https://doi.org/10.1038/nsb0597-374 DO - 10.1038/nsb0597-374 ID - Corper1997 ER - TY - JOUR AU - Duquerroy, S. AU - Stura, E. A. AU - Bressanelli, S. AU - Fabiane, S. M. AU - Vaney, M. C. AU - Beale, D. AU - Hamon, M. AU - Casali, P. AU - Rey, F. A. AU - Sutton, B. J. PY - 2007 DA - 2007// TI - Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 fc reveals a novel epitope and evidence for affinity maturation JO - J Mol Biol VL - 368 UR - https://doi.org/10.1016/j.jmb.2007.02.085 DO - 10.1016/j.jmb.2007.02.085 ID - Duquerroy2007 ER - TY - STD TI - NLM format citation: Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, Leipold MD, Lin DTS, Kobor MS, Horvath S. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019;18(6):e13028. https://doi.org/10.1111/acel.13028. Epub 2019 Sep 8. PMID: 31496122; PMCID: PMC6826138. ID - ref45 ER - TY - JOUR AU - Weyand, C. M. AU - Goronzy, J. J. PY - 2016 DA - 2016// TI - Aging of the Immune System. Mechanisms and Therapeutic Targets JO - Ann Am Thorac Soc VL - 13 UR - https://doi.org/10.1513/AnnalsATS.201602-095AW DO - 10.1513/AnnalsATS.201602-095AW ID - Weyand2016 ER - TY - JOUR AU - Montecino-Rodriguez, E. AU - Berent-Maoz, B. AU - Dorshkind, K. PY - 2013 DA - 2013// TI - Causes, consequences, and reversal of immune system aging JO - J Clin Invest VL - 123 UR - https://doi.org/10.1172/JCI64096 DO - 10.1172/JCI64096 ID - Montecino-Rodriguez2013 ER - TY - JOUR AU - Marko, M. G. AU - Ahmed, T. AU - Bunnell, S. C. AU - Wu, D. AU - Chung, H. AU - Huber, B. T. AU - Meydani, S. N. PY - 2007 DA - 2007// TI - Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation JO - J Immunol VL - 178 UR - https://doi.org/10.4049/jimmunol.178.3.1443 DO - 10.4049/jimmunol.178.3.1443 ID - Marko2007 ER - TY - JOUR AU - Bonagura, V. R. AU - Agostino, N. AU - Børretzen, M. AU - Thompson, K. M. AU - Natvig, J. B. AU - Morrison, S. L. PY - 1998 DA - 1998// TI - Mapping IgG epitopes bound by rheumatoid factors from immunized controls identifies disease-specific rheumatoid factors produced by patients with rheumatoid arthritis JO - J Immunol VL - 160 ID - Bonagura1998 ER - TY - JOUR AU - Esch, W. J. AU - Reparon-Schuijt, C. C. AU - Hamstra, H. J. AU - Kooten, C. AU - Logtenberg, T. AU - Breedveld, F. C. AU - Verweij, C. L. PY - 2003 DA - 2003// TI - Human IgG fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection JO - Clin Exp Immunol VL - 131 UR - https://doi.org/10.1046/j.1365-2249.2003.02068.x DO - 10.1046/j.1365-2249.2003.02068.x ID - Esch2003 ER - TY - JOUR AU - Prokunina, L. AU - Padyukov, L. AU - Bennet, A. AU - Faire, U. AU - Wiman, B. AU - Prince, J. AU - Alfredsson, L. AU - Klareskog, L. AU - Alarcón-Riquelme, M. PY - 2004 DA - 2004// TI - Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope JO - Arthritis Rheum VL - 50 UR - https://doi.org/10.1002/art.20280 DO - 10.1002/art.20280 ID - Prokunina2004 ER - TY - JOUR AU - Westwood, O. M. AU - Nelson, P. N. AU - Hay, F. C. PY - 2006 DA - 2006// TI - Rheumatoid factors: what's new? JO - Rheumatology (Oxford) VL - 45 UR - https://doi.org/10.1093/rheumatology/kei228 DO - 10.1093/rheumatology/kei228 ID - Westwood2006 ER -