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Table 4 Age and Laboratory results. Association to COVID-19 severity and evolution from admission to discharge

From: COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study

 

Severity p-value

Δa-da p-value

n

mean

median

SDb

IQRc

Age

< 0.001(A)

      

 Mild

  

160

58.96

61.00

17.08

49–70.5

 Moderate

  

246

64.08

66.00

16.05

54–77

 Severe

  

178

65.25

65.50

15.98

54–79

On admission

IL6d (pg/mL)

< 0.001

      

  Mild

  

78

31.40

17.60

40.53

9–40.9

  Moderate

  

98

77.86

43.10

155.30

19.5–87.3

  Severe

  

78

241.16

87.45

597.92

30.4–239.7

CRPe (mg/L)

< 0.001

      

  Mild

  

132

66.21

44.45

67.83

17.45–85.2

  Moderate

  

231

108.82

93.00

83.25

43.8–147

  Severe

  

160

152.14

128.40

107.91

64.25–217.65

ferritin (ng/mL)

< 0.001

      

  Mild

  

80

711.39

491.45

881.96

201.65–874

  Moderate

  

133

1003.30

775.00

902.63

390–1479

  Severe

  

84

1653.65

1073.50

2404.04

713.5–1796.5

D-dimer (ng/mL)

< 0.001

      

  Mild

  

120

1083.58

522.00

3684.33

340.5–797

  Moderate

  

200

1442.13

594.00

3878.02

391.5–1025

  Severe

  

136

3243.72

960.50

13,804.06

468.5–1586

LDHf (U/L)

< 0.001

      

  Mild

  

124

252.55

244.50

75.01

200–292.5

  Moderate

  

208

314.61

292.50

123.08

240–372.5

  Severe

  

135

438.99

401.00

274.08

279–524

Leucocyte count (cells*103/μL)

< 0.001

      

  Mild

  

147

6.25

5.70

2.46

4.68–7.03

  Moderate

  

246

7.60

6.15

7.16

4.70–8.82

  Severe

  

177

8.65

7.89

4.73

5.50–10.3

Neutrophil count (cells*103/μL)

< 0.001

      

  Mild

  

147

4.33

3.89

2.22

3.00–5.17

  Moderate

  

246

5.39

4.32

3.74

3.20–7.00

  Severe

  

177

7.10

6.40

4.13

4.30–8.71

Lymphocyte count (cells*103/μL)

0.048

      

  Mild

  

147

1.29

1.10

0.76

0.86–1.57

  Moderate

  

246

1.13

0.97

0.85

0.73–1.33

  Severe

  

177

1.10

0.90

1.47

0.59–1.24

Lymphocyte %

< 0.001

      

  Mild

  

147

22.04

19.70

11.14

14.7–28.7

  Moderate

  

246

18.55

17.10

10.99

9.8–24.5

  Severe

  

177

14.64

12.00

11.01

7.5–18.1

CD3 + CD4+ %

       

  Mild

  

8

41.31

41.10

6.56

36–47.1

  Moderate

  

35

45.84

46.50

12.52

38.3–52.8

  Severe

  

12

41.04

41.90

11.25

34.3–50.4

CD3 + CD4+ count (cells*103/μL)

  Mild

  

8

0.74

0.71

0.46

0.32.35–1.1

  Moderate

  

33

0.56

0.44

0.39

0.27–0.69

  Severe

  

13

0.36

0.32

0.20

0.27–0.46

CD3 + CD8+ %

  Mild

  

8

26.23

27.00

4.26

22.7–28.9

  Moderate

  

35

21.74

20.30

10.66

12.09–30.5

  Severe

  

12

26.57

28.30

9.18

19.39–32.4

CD4 + CD8+ count (cells*103/μL)

0.041(A)

      

  Mild

  

8

0.45

0.41

0.28

0.20–0.70

  Moderate

  

33

0.25

0.18

0.20

0.13–0.35

  Severe

  

13

0.24

0.24

0.18

0.084–0.30

CD19+ %

       

  Mild

  

8

11.50

10.90

3.36

8.95–13

  Moderate

  

35

12.47

10.60

6.99

7.3–16

  Severe

  

9

15.97

12.00

10.61

10.3–14.83

CD19+ count (cells*103/μL)

  Mild

  

8

0.19

0.18

0.11

0.09–0.29

  Moderate

  

33

0.12

0.09

0.09

0.06–0.20

  Severe

  

10

0.16

0.10

0.08

0.06–0.12

Natural Killer %

       

  Mild

  

8

15.59

13.80

8.96

8.55–23.55

  Moderate

  

35

16.06

15.50

8.36

11.8–20.7

  Severe

  

9

15.67

11.40

10.90

6.8–20.6

Natural Killer count (cells*103/μL)

  Mild

  

8

0.23

0.16

0.15

0.12–0.37

  Moderate

  

33

0.17

0.16

0.12

0.08–0.21

  Severe

  

10

0.11

0.12

0.06

0.09–0.14

IgG (mg/dL)

0.048

      

  Mild

  

1

1006.00

1006.00

.

1006–1006

  Moderate

  

13

998.31

934.00

133.23

915–1071

  Severe

  

5

857.20

862.00

76.43

788–885

IgA (mg/dL)

  Mild

  

1

248.00

248.00

.

248–248

  Moderate

  

13

234.00

223.00

86.48

175–248

  Severe

  

5

219.40

218.00

28.98

213–230

IgM (mg/dL)

0.009

      

  Mild

  

1

129.00

129.00

.

129–129

  Moderate

  

13

118.00

121.00

34.88

88–141

  Severe

  

5

59.20

58.00

13.83

50–72

At discharge

IL6 (pg/mL)

0.017

      

  Mild

  

55

21.17

11.60

28.51

4.77–23.2

  Moderate

 

< 0.001

50

47.04

7.26

126.46

1.88–13.4

  Severe

  

12

677.75

24.86

2204.56

9.1–59.63

CRP (mg/L)

 

< 0.001

     

  Mild

  

115

27.69

14.30

32.92

6.3–38.1

  Moderate

  

137

29.93

13.93

42.69

4–36

  Severe

  

45

35.86

8.00

71.26

4–25.2

ferritin (ng/mL)

< 0.001

      

  Mild

  

77

611.96

386.00

646.97

245–793

  Moderate

  

94

778.67

687.50

599.84

331–1178

  Severe

  

38

3783.41

1085.90

15,135.72

571–1776

D-dimer (ng/mL)

< 0.001

      

  Mild

  

94

705.22

463.50

937.24

326–751

  Moderate

  

130

5219.08

586.00

48,290.67

356–1040

  Severe

 

< 0.001

47

2870.13

1415.00

4230.08

792–3912

LDH (U/L)

< 0.001

0.004

     

  Mild

  

102

238.22

218.00

78.79

192–261

  Moderate

  

124

247.19

235.50

83.32

192–271

  Severe

  

47

820.53

286.00

2722.15

242–400

Leucocyte count (cells*103/μL)

< 0.001

0.013

     

  Mild

  

127

6.26

5.80

2.59

4.78–7.21

  Moderate

  

146

7.46

6.90

3.08

5.30–9.20

  Severe

  

53

10.10

8.31

6.41

5.79–12.33

Neutrophil count (cells*103/μL)

< 0.001

      

  Mild

 

< 0.001

127

4.12

3.54

2.56

2.67–4.50

  Moderate

  

146

5.07

4.40

2.99

3.09–6.20

  Severe

  

53

8.01

6.50

6.18

3.78–9.60

Lymphocyte count (cells*103/μL)

 

< 0.001

     

  Mild

  

127

1.50

1.45

0.62

1.06–1.89

  Moderate

  

146

1.54

1.40

0.87

0.97–1.87

  Severe

  

53

1.52

1.54

0.77

0.8–2.02

Lymphocyte %

0.006

0.007

     

  Mild

  

127

25.47

26.10

9.31

19.4–32.1

  Moderate

  

146

23.12

22.65

12.73

13.7–30.3

  Severe

  

53

19.41

18.40

13.34

8.6–26.6

CD3 + CD4+ %

  Mild

  

3

49.33

54.00

13.61

34–60

  Moderate

  

11

47.66

53.00

16.84

49–58.24

  Severe

  

0

    

CD3 + CD8+ %

  Mild

  

3

20.33

20.00

11.50

9–32

  Moderate

  

11

19.50

17.00

10.22

10–29.27

  Severe

  

0

    

CD19%

  Mild

  

3

15.00

17.00

6.24

8–20

  Moderate

  

11

17.51

10.86

22.97

7–15

  Severe

  

0

    

Natural Killer %

  Mild

  

3

13.67

15.00

4.16

9–17

  Moderate

  

11

12.85

11.00

8.38

7–17.3

  Severe

  

0

    
  1. Abbreviations: Severity p-values come from Kruskal-Wallis median test unless (A) marked, those p values come from One-Way ANOVA so far the parameter follows a normal distribution and its n > 30: Δa-da, differences between admission and discharge (Wilcoxons’ test for paired samples p-values); SDb Standard deviation, IQRc Interquartile range, IL6d Interleukin 6, CRPe C-reactive protein, LDHf Lactate dehydrogenase