Fig. 2

Age and HLA-I polymorphism independently affect TCR repertoire diversity in CMV- individuals. a No association between age and number of unique CDR3s in CMV+ individuals; age P = 0.41, estimate = − 378.5; HLA-I P = 0.70, estimate = − 3318.9. P-values are from a linear model incorporating age and number of unique HLA-I alleles. b Association between age and number of unique CDR3s in CMV- individuals; age P = 0.002, estimate = − 1326.3; HLA-I P = 0.02, estimate = 18,787.8. P-values are from a linear model incorporating age and number of unique HLA-I alleles. c AIC analysis of three linear models with number of unique CDR3s as the dependent variable, and either age alone, number of unique HLA-I alleles alone, or both as the independent variables. All models were fit in CMV- individuals. Data show that the best model that explains the observed TCR repertoire diversity across these individuals is the one with both age and number of unique HLA-I alleles (AIC = 4601.28)