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Fig. 1 | Immunity & Ageing

Fig. 1

From: ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals

Fig. 1

PBMCs from aged individuals show reduced frequencies of ARID3a+ HSCs. Human HSCs expressing ARID3a were identified by flow cytometry from total PBMCs of 54 healthy adults (ages 18–70). a Representative gating from young (left) and aged (center) donors, with an isotype control for ARID3a (right) are shown. b Numbers of HSCs/ml of blood are plotted against age with a line of best fit. Red samples indicate samples from donors ≥65 years of age. c Frequencies of ARID3a+ HSCs are plotted against age. Frequencies (d) and numbers (e) of ARID3a+ HSCs for young (triangles) and aged (diamonds) donors are shown. f Mean Fluorescence Intensities (MFI) of ARID3a+ HSCs from young and aged donors are presented. Averages and standard error bars are shown. Statistical significance was determined by Mann Whitney U test and Pearson’s Correlation

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