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Table 2 Levels of serum cytokines

From: Reproducibility of serum cytokines in an elderly population

Cytokines

Intra-assay CV (%)

Inter-assay CV (%)

Detectable proportions (%) a

Median (P25-P75) (pg/mL)

Range (pg/mL)

EGF

0.91

7.19

99.49

226.71 (126.59, 374.77)

<  3.17 to 1657

Eotaxin

1.37

3.48

100

134.79 (98.66, 183)

8.46 to 562.15

FGF-2

1.68

7.56

88.72

48.23 (23.39, 105.09)

<  13.05 to 429.02

Flt-3 L

3.17

7.99

48.21

3.29 (3.29, 30.1)

<  4.65 to 1769

Fractalkine

2.05

12.69

43.59

21.48 (18.72, 61.34)

<  26.48 to > 9834

G-CSF

3.06

8.69

91.28

20.45 (11.17, 49.02)

<  3.97 to 404.65

GM-CSF

7.45

6.89

80.51

7.58 (3.54, 17.48)

<  3.16 to 1287

GRO

1.07

4.65

77.44

2216 (1264, 7288.5)

470.26 to > 9906

IFNα2

5.34

5.92

55.90

7.9 (3.23, 25.39)

<  4.57 to 924.48

IFNγ

0.44

8.50

75.38

5.06 (2.07, 11.76)

<  2.04 to 1183

IL-10

5.26

4.49

25.13

2.21 (2.21, 3.21)

<  3.13 to 1304

IL-12p40

3.47

6.37

30.26

4.79 (4.79, 11.68)

<  6.78 to 605.62

IL-12p70

0.99

2.68

27.69

2.02 (2.02, 3.74)

<  2.85 to 655.57

IL-13

3.05

5.86

26.15

3.33 (3.33, 6.25)

<  4.71 to 598.37

IL-15

4.94

6.30

34.36

2.04 (2.04, 4.3)

<  2.88 to 153.79

IL-17

2.90

4.36

70.77

2.57 (0.73, 7.72)

<  1.03 to 451.19

IL-1α

9.92

5.47

43.59

3.6 (3.6, 25.14)

<  5.09 to 3539

IL-1β

5.15

8.15

53.33

1.48 (0.88, 4.86)

<  1.24 to 2581

IL-1RA

3.02

8.20

90.26

15.7 (7.66, 31.01)

<  3.65 to 3857

IL-2

3.14

4.48

28.72

1.98 (1.98, 3.62)

<  2.80 to 86.71

IL-3

11.71

12.30

4.62

1.97 (1.97, 1.97)

<  2.78 to 13.07

IL-4

8.57

7.22

83.51

31.18 (9.96, 79.75)

<  5.42 to 375.29

IL-5

4.03

1.87

22.05

0.76 (0.76, 0.94)

<  1.07 to 72.28

IL-6

4.99

6.19

42.56

1.32 (1.32, 19.72)

<  1.86 to 7220

IL-7

5.37

4.70

43.59

2.64 (2.34, 7.73)

<  3.31 to 119.38

IL-8

2.91

4.22

97.44

36.4 (15.12, 245.41)

3.84 to > 9613

IL-9

3.91

5.98

15.38

1.99 (1.99, 1.99)

<  2.81 to 128.69

IP-10

2.69

3.44

100

222.35 (175.6, 307.84)

49.15 to 1009

MCP-1

3.53

5.93

100

590.84 (429.88, 902.12)

118.05 to 9309

MCP-3

0.72

5.50

61.54

6.17 (2.47, 34.91)

<  3.50 to 2891

MDC

9.14

8.11

100

1043 (758.06, 1409)

234.05 to 6725

MIP-1α

8.53

5.06

88.21

19.24 (6.44, 69.77)

<  3.12 to > 5472

MIP-1β

0.65

6.53

99.49

48.04 (28, 89.12)

<  4.50 to 1251

PDGF-AA

2.00

3.91

99.49

3576 (2533.5, 4803.5)

305.27 to > 8786

PDGF-AB/BB

6.91

9.83

30.77

9490 (8841, 9490)

3148 to > 9490

RANTES

8.08

12.69

96.92

2730 (1845.5, 3724.5)

619.28 to > 13,438

sCD40L

1.74

6.59

84.10

9529 (4893.5, 13,789)

<  2.86 to > 17,067

TGFα

1.09

16.03

66.15

4.72 (2.18, 8.31)

<  3.09 to > 5120

TNFα

2.78

7.59

95.90

16.48 (9.66, 27.52)

<  2.93 to 716.76

TNFβ

4.15

5.78

19.49

2.01 (2.01, 2.01)

<  2.84 to 639.95

VEGF

4.22

7.00

88.21

161.45 (71.86, 326.21)

<  20.50 to 919.48

  1. CV coefficient of variation, P25-P75 the 25th to the 75th percentiles, EGF epidermal growth factor, FGF-2 fibroblast growth factor 2, Flt-3 L fms-like tyrosine kinase 3 ligand, G-CSF granulocyte colony-stimulating factor, GM-CSF granulocyte macrophage colony-stimulating factor, GRO growth regulated oncogene, IFNα2 interferon alpha 2, IFNγ interferon gamma, IL interleukin, IL-1RA interleukin-1 receptor antagonist, IP-10 interferon gamma-induced protein 10, MCP monocyte chemotactic protein, MDC macrophage-derived chemokine, MIP macrophage inflammatory proteins, PDGF platelet-derived growth factor, RANTES regulated on activation, normal T cell expressed and secreted, TGF transforming growth factor, TNF tumor necrosis factor, VEGF vascular endothelial growth factor, sCD40L soluble cluster of differentiation 14 ligand.
  2. aValues in bold mean that the proportions of subjects with detectable values (between LLOD and ULOD) were <  60%. A total of 18 cytokines were excluded in the further data analyses due to the low detectable rate
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Immunity & Ageing

ISSN: 1742-4933

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