Table 2 Serologic characteristics of different types of AIHA [3, 11, 74]
From: Autoimmune hemolytic anemia: current knowledge and perspectives
Type of AIHA | Antibody type | Typical DAT | RBC eluate | Antigen specifity | Antibody titre at 4 °C |
|---|---|---|---|---|---|
Warm AIHA | IgG (rarely IgA or IgM) | IgG or IgG + C3 | IgG | panreactive | – |
CAD | IgM | C3 | nonreactive | usually anti-Ia | usually > 1:500 |
PCH | biphasic IgG | C3 | nonreactive | usually anti-P | < 1:64 |
Mixed AIHA | IgG, IgM | IgG + C3 | IgG | usually lack specifity of warm IgG, cold antibody differentlyb | cold antibodies < 1:64 |
DIHA | Ig G | IgG or IgG + C3 | IgG | often Rh-related | – |