Table 4 Complement modulation in AIHA treatment: now and in the future
From: Autoimmune hemolytic anemia: current knowledge and perspectives
Level of complement pathway modulation | Novel agents | Comments |
|---|---|---|
C1 complex (C1q, C1r, C1s) | ANX005 | anti-C1q monoclonal antibody |
TNT003 | anti-C1s monoclonal antibody | |
PIC1 | peptide inhibitor | |
Sutimlimab | anti-C1s monoclonal antibody | |
C3 complement | Compstatin Cp40 | long-acting form polyethylene glycol |
Pegcetacoplan (APL2) | pegylated compstatin analog | |
C5 complement | Eculizumab | anti-C5 monoclonal antibody |