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Table 2 Cell Frequencies Significantly Correlated Between Younger and/or Middle-aged Twins

From: Aging and CMV discordance are associated with increased immune diversity between monozygotic twins

Cell type

Young twins Spearman’s rank correlation*

Middle-aged twins Spearman’s rank correlation

Young twins FDR-adjusted P

Middle-aged twins FDR-adjusted P

Older twins Spearman’s rank correlation from Brodin et al. [12]

IgD+ CD27- B cells

0.65

0.88

0.039

0.020

0.68

IgD- CD27+ B cells

0.70

0.86

0.020

0.020

0.6

IgD- CD27- B cells

0.72

0.87

0.020

0.020

0.56

CD16+ Monocytes

0.56

0.88

0.082

0.020

NA

CD4+ T cells

0.62

0.80

0.046

0.039

0.76

CD28+ CD4+ T cells

0.75

0.93

0.020

0.012

NA

CD8+ T cells

0.65

0.87

0.039

0.020

0.68

Effector Memory CD8+ T cells

0.61

0.73

0.053

0.071

0.9

CD94+ NK cells

0.55

0.78

0.083

0.039

NA

CD161+ CD45RA- Tregs

1.00

0.85

< 0.001

0.028

0.97

Tregs

0.80

0.67

0.015

0.095

0.24

B cells

0.67

0.43

0.038

0.34

0.25

IgD+ CD27+ B cells

0.53

0.47

0.095

0.27

0.51

Naïve B cells

0.67

0.28

0.039

0.52

0.85

Transitional B cells

0.73

0.55

0.020

0.19

0.28

Central Memory CD4+ T cells

0.64

0.38

0.041

0.40

0.55

CD94+ CD4+ T cells

0.73

0.25

0.020

0.56

NA

CD27+ CD4+ T cells

0.71

0.64

0.020

0.12

NA

CD161+ CD4+ T cells

0.72

0.52

0.020

0.23

NA

CD161- CD8+ T cells

0.64

0.32

0.040

0.47

NA

CD27- CD8+ T cells

0.58

0.32

0.071

0.47

NA

CD28- CD8+ T cells

0.63

0.28

0.045

0.52

NA

CD94+ CD8+ T cells

0.72

0.22

0.020

0.63

NA

CD85j + CD8+ T cells

0.54

0.35

0.095

0.45

NA

Effector CD8+ T cells

0.72

0.15

0.020

0.74

0.28

CD161- CD45RA+ Tregs

0.72

−0.06

0.020

0.15

0.66

CD161+ NK cells

0.71

0.58

0.020

0.17

NA

NKT cells

0.75

0.35

0.020

0.45

0.7

Lymphocytes

0.49

0.78

0.14

0.044

0.8

CD85j- CD4+ T cells

0.40

0.88

0.23

0.020

NA

Effector CD4+ T cells

0.46

0.78

0.19

0.039

0.7

  1. * Medians of the repeated calculations of Spearman’s rank correlation coefficients are reported (see methods)
  2. Statistically significant results (FDR-adjusted P < 0.1) are bolded