Aging and CMV discordance are associated with increased immune diversity between monozygotic twins

Immunity & Ageing

Table 3 Cell Frequencies Significantly Correlated Between CMV−/− (n = 8 pairs) and/or CMV−/+ (n = 5 pairs) Twins

Cell type	CMV −/− twins Spearman’s rank correlation*	CMV −/+ twins Spearman’s rank correlation	CMV −/− twins FDR-adjusted P	CMV −/+ twins FDR-adjusted P
IgD- CD27- B cells	0.88	1.00	0.077	0.091
CD28+ CD4+ T cells	0.93	1.00	0.061	0.091
IgD+ CD27- B cells	0.95	0.10	0.047	0.95
IgD- CD27+ B cells	0.83	0.30	0.085	0.81
Transitional B cells	0.85	0.60	0.077	0.56
CD4+ T cells	0.83	0.50	0.091	0.66
CD85j- CD4+ T cells	0.93	0.10	0.047	0.95
CD8+ T cells	0.86	0.50	0.085	0.66
Effector memory CD8+ T cells	0.89	0.40	0.069	0.69
CD161+ CD45RA- Tregs	0.84	0.92	0.078	0.12
NKT cells	0.86	0.15	0.077	0.92
CD94+ NK cells	0.41	0.97	0.55	0.077
Tregs	0.78	1.00	0.12	0.091

* For the CMV concordant negative twins, medians of the repeated calclations of Spearman’s rank correlations are reported (see methods)
Statistically significant results (FDR-adjusted P < 0.1) are bolded

ISSN: 1742-4933