Fig 1From: An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)Loss of immune tolerance in an ageing immune system. T cells /B cells in primary lymphoid organs plus peripheral T cells express tolerance checkpoint proteins . Biological ageing-associated ISC causes a decline in immune tolerance. Self-reactive immune cells develop and recruit inflammatory cells . Tissue-dependent autoimmune reactions and destructive mechanisms evolveBack to article page