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Fig. 1 | Immunity & Ageing

Fig. 1

From: Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans

Fig. 1

Age differences in frequencies of LPMC memory T cells isolated from Ty21a-vaccinated and unvaccinated volunteers. Comparison of TM subsets including TCM (CD62L+ CD45RA−), TEM (CD62L- CD45RA-), TEMRA (CD62L- CD45RA+), and Tnaive (CD62L+ CD45RA+) between adults (A; < 60 yrs.) and elderly (E; ≥60 yrs.) in TI-LPMC (a) CD4+ T and (b) CD8+ T cells obtained from Ty21a-vaccinated (red symbols) and unvaccinated (black symbols) volunteers. Frequencies of (c) TI-LPMC CD4+ CD103+ and CD4+ CD103- TRM and (d) TI-LPMC CD8+ CD69+ CD103+ (CD8+ TRM) and CD8+ CD69+ CD103- T cells were determined and compared between adults and elderly volunteers following Ty21a immunization. Median values for each group are denoted as horizontal black bars. Significant differences are denoted with *P < 0.05, **P < 0.005. Trends to exhibit significance values are indicated by their p-values

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