Fig. 5
From: Functional conservation in genes and pathways linking ageing and immunity
Antiviral RNAi pathway. The antiviral RNA interference (RNAi) pathway shows genetic and functional conservation across D. melanogaster, C. elegans and mammals. In both, C. elegans and D. melanogaster, antiviral RNAi is thought to be a major innate defence against viruses. However, even though antiviral RNAi exists in mammals, its importance is currently under debate as they contain other potent mechanisms of virus defence, such as the interferon response and adaptive immunity. Components also involved in lifespan in at least one of the represented species are marked in green and bold