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Table 2 The Cox proportional hazards model for mortality and unexpected admission

From: CMV infection, CD19+ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly

Variables Unexpected admission: OR (95% CI) Mortality: OR (95% CI)
Unadjusted Model 1 Model 2 Unadjusted Model 1 Model 2
CMV IgG, IU/mL
  < 174.1 1 1 1 1 1 1
 174.1–236.8 1.23 (0.63, 2.39) 1.24 (0.62, 2.47) 2.05 (0.93, 4.51) 1.31 (0.52, 3.34) 1.37 (0.53, 3.5) 1.63 (0.57, 4.67)
 236.8–722.1 2.56 (1.41, 4.64)** 2.84 (1.56, 5.2)** 3.26 (1.55, 6.84)** 1.36 (0.54, 3.38) 1.15 (0.45, 2.89) 0.92 (0.31, 2.66)
  > 722.1 1.65 (0.88, 3.12) 1.7 (0.89, 3.24) 2.02 (0.97, 4.18) 1.49 (0.6, 3.71) 1.17 (0.46, 2.95) 0.97 (0.35, 2.67)
HCV IgG, S/CO
  < 0.0575 1 1 1 1 1 1
 0.0575–0.07 0.85 (0.45, 1.58) 0.96 (0.51, 1.83) 1.1 (0.5, 2.42) 0.41 (0.17–0.97)* 0.51 (0.21, 1.26) 0.53 (0.18, 1.53)
 0.07–0.1 1.03 (0.55–1.91) 1.39 (0.72, 2.67) 1.62 (0.77, 3.39) 0.58 (0.25, 1.32) 0.85 (0.35, 2.06) 0.95 (0.34, 2.58)
  > 0.1 1.63 (0.91, 2.91) 1.71 (0.92, 3.18) 1.84 (0.91, 3.72) 0.53 (0.22, 1.26) 0.65 (0.26, 1.59) 0.65 (0.23, 1.81)
Lymphopenia 3.43 (1.8, 6.5)*** 2.97 (1.51, 5.82)** 2.85 (1.2, 6.74)** 2.91 (1.29, 6.6)* 2.32 (1, 5.33)* 1.9 (0.66, 5.4)
CD3+ T cell count, cells/cumm
  > 1526 1 1 1 1 1 1
 1136- 1526 0.97 (0.5, 1.88) 0.77 (0.38, 1.53) 0.43 (0.18, 1) 0.43 (0.13, 1.4) 0.21 (0.06, 0.73)* 0.19 (0.05, 0.71)*
 903–1136 1.42 (0.77, 2.65) 0.98 (0.49, 1.92) 0.72 (0.34, 1.54) 1.12 (0.45, 2.76) 0.5 (0.19, 1.33) 0.59 (0.2, 1.73)
  < 903 2.22 (1.23, 4.02)** 1.54 (0.78, 3.03) 1.04 (0.47, 2.28) 2.07 (0.91, 4.7) 1 (0.4, 2.47) 0.94 (0.33, 2.7)
CD4+ T cell count, cells/cumm
  > 926 1 1 1 1 1 1
 718–926 1.34 (0.66, 2.69) 1.06 (0.51, 2.22) 0.63 (0.27, 1.46) 1.45 (0.46, 4.58) 1 (0.31, 3.18) 0.95 (0.27, 3.38)
 557–718 2.15 (1.13, 4.11)* 1.55 (0.77, 3.12) 1.11 (0.52, 2.37) 2.23 (0.77, 6.42) 1.24 (0.42, 3.68) 1.31 (0.41, 4.13)
  < 557 2.78 (1.46, 5.3)** 1.75 (0.84, 3.67) 1.57 (0.71, 3.46) 3.88 (1.42, 10.61)** 2.15 (0.75, 6.14) 2.55 (0.8, 8.06)
CD19+ B cell count, cells/cumm
  > 205 1 1 1 1 1 1
 135–205 2.07 (1.06, 4.04)* 1.76 (0.86, 3.6) 1.59 (0.73, 3.46) 1.46 (0.46, 4.62) 0.97 (0.3, 3.12) 0.99 (0.28, 3.5)
 81–135 1.54 (0.77, 3.08) 1.24 (0.57, 2.71) 1.05 (0.45, 2.48) 2.42 (0.84, 6.98) 1.35 (0.44, 4.12) 1.11 (0.34, 3.64)
  < 81 3.1 (1.64, 5.84)*** 2.24 (1.09, 4.63)* 2.84 (1.29, 6.25)** 3.67 (1.34, 10.03)* 1.99 (0.68, 5.81) 2.41 (0.79, 7.36)
  1. *p < 0.05, **p < 0.01, ***p < 0.001
  2. Model 1: Adjusted by age, gender, body mass index, highly-sensitive C-reactive protein, and multimorbidity by Charlson comorbidity index
  3. Model 2: Adjusted by education status, cigarette smoking, alcohol consumption, albumin, low density lipoprotein cholesterol, medical history of acute myocardial ischemia, congestive heart failure, cerebrovascular accident, and diabetes mellitus, in addition to age, gender, body mass index, and multimorbidity