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Fig. 3 | Immunity & Ageing

Fig. 3

From: Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

Fig. 3

Effect of LPS and P. gingivalis on TLR4 (CD284) and TLR2 (CD282) expression in monocytes of healthy, SMC, MCI and AD individuals. Monocytes were cultured in the absence ( - ) or presence ( + ) of LPS (100ng/ml) or Pg supernatant (20μg) for 1 hr at 37°C, 5% CO2 air mixture, stained for TLR4 (CD284) TLR2 (CD282) and analyzed by flow cytometry as in M&M. a TLR4 ± LPS. b TLR4 ± Pg. c TLR2 ± LPS. d TLR2 ± Pg. Each dot corresponds to one individual. Statistical analyses were performed by Student t-testing to assess differences within each patient group. Data are a combination of 18 independent experiments and are shown as mean of MFI ± SD. The asterisks correspond to *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001

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