Fig. 3From: Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's diseaseEffect of LPS and P. gingivalis on TLR4 (CD284) and TLR2 (CD282) expression in monocytes of healthy, SMC, MCI and AD individuals. Monocytes were cultured in the absence ( - ) or presence ( + ) of LPS (100ng/ml) or Pg supernatant (20μg) for 1 hr at 37°C, 5% CO2 air mixture, stained for TLR4 (CD284) TLR2 (CD282) and analyzed by flow cytometry as in M&M. a TLR4 ± LPS. b TLR4 ± Pg. c TLR2 ± LPS. d TLR2 ± Pg. Each dot corresponds to one individual. Statistical analyses were performed by Student t-testing to assess differences within each patient group. Data are a combination of 18 independent experiments and are shown as mean of MFI ± SD. The asterisks correspond to *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001Back to article page