Fig. 4

Histopathology of Articular Cartilage Following Systemic Transplantation of Young MDSPCs in Zmpste24^−/− Mice. a Representative images (20x magnification) of Safranin-O (Saf-O) stained femoral condyle and tibial plateau from PBS- (Z-PBS, n = 3) and MDSPC-intraperitoneally transplanted (Z-IP; n = 3) Zmpste24^−/− mice at 5–6 months of age. Quantitative histomorphometric analysis shows (b) total cartilage area, (c) percent of Saf-O + cartilage area, (d) chondrocyte number, and (e) chondrocyte density. Data are mean ± SEM. *p < 0.05 with two-tailed, unpaired Student’s t-test