Fig. 5

B cells from young and elderly HIV individuals, as compared to those from healthy controls, express higher levels of mRNA of enzymes involved in metabolic pathways. B cells, isolated as described in Fig. 2, were left unstimulated. a The RNA was extracted and qPCR performed to evaluate RNA expression of LDHA (left) and PDHX (right). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. b PCA analyses with the axes showing the percentage of variation explained by PC1 and PC2. Each symbol corresponds to one individuals. Open circles, young healthy donors; filled circles, elderly healthy donors; open squares, young HIV + individuals; filled circles, elderly HIV + individuals