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Table 2 Association of immunity markers with risk of incident frailty in non-frail individuals

From: Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study

 

Model 1

Model 2

OR (95% CI)

P-value

OR (95% CI)

P-value

All individuals

 NLR

2.14 (0.98, 4.67)

0.056

2.92 (1.20, 7.18)

0.019

 PLR

2.72 (1.18, 6.34)

0.019

2.54 (1.01, 6.53)

0.050

 SII

2.14 (1.14, 4.03)

0.018

2.34 (1.16, 4.78)

0.019

 Neutrophil count

1.58 (0.54, 4.64)

0.406

2.49 (0.72, 8.72)

0.151

 Platelet count

2.39 (0.81, 7.36)

0.122

1.70 (0.51, 6.00)

0.398

 Lymphocytes count

0.34 (0.12, 0.99)

0.048

0.30 (0.09, 1.00)

0.051

Without comorbidities

 NLR

3.13 (1.31, 7.47)

0.010

4.21 (1.54, 11.62)

0.005

 PLR

3.58 (1.39, 9.30)

0.009

3.38 (1.17, 9.91)

0.025

 SII

2.50 (1.23, 5.09)

0.012

2.56 (1.15, 5.72)

0.021

 Neutrophil count

1.73 (0.51, 5.89)

0.376

2.33 (0.56, 9.76)

0.244

 Platelet count

2.03 (0.60, 7.19)

0.261

1.32 (0.33, 5.47)

0.697

 Lymphocytes count

0.18 (0.06, 0.59)

0.005

0.14 (0.04, 0.54)

0.004

  1. NLR: neutrophil-lymphocytes ratio, PLR: platelet-to-lymphocyte ratio, SII: systemic immune-inflammation index, OR: odds ratio, CI: confidence interval, Model 1: unadjusted, Model 2: adjusted for age, gender, BMI, smoking, alcohol assumption, educational status, marital status, regular exercise, elf-reported hypertension, triglyceride, high-density lipoprotein, low-density lipoprotein, fasting blood glucose, and comorbidity (in all individuals). All immunity markers were logarithmically transformed. Analysis for each blood cell type adjusted for the baseline blood cell counts of the remaining two blood cell types