Table 1 Controversial findings on aging influence on CD4+ T-cell recovery

Kaufmann et al., JAMA, 2003 [3]

2235

4 years

Older age (> 40 years) ↓ CD4+ T-cell change by 39 cells/μl over 48 months

Moore et al., CID, 2007 [5]

655

6 years

Older age (> 45 years) ↓ CD4+ cell change by 60 cells/μl over 6 years

Li et al., JAIDS, 2011 [4]

614 men

5 – 12 years

Older age (≥50 years) ↓ CD4+ T-cell counts by 59 cells/μl over 5-12 years

Greenbaum, AIDS, 2008 [2]

906

4 years

Nonsignificant difference in time to increase by 50 cells/μL or mean increase in CD4+ T-cells from baseline between > 50 years vs. < 40 years

Wright et al., HIV medicine, 2013 [6]

3378

≥ 5 years

Nonsignificant difference in CD4+ T-cell increase rate in > 50 years vs. others