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Table 1 Controversial findings on aging influence on CD4+ T-cell recovery

From: The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study

Citation Sample size Study length The effect of age
Kaufmann et al., JAMA, 2003 [3] 2235 4 years Older age (> 40 years) ↓ CD4+ T-cell change by 39 cells/μl over 48 months
Moore et al., CID, 2007 [5] 655 6 years Older age (> 45 years) ↓ CD4+ cell change by 60 cells/μl over 6 years
Li et al., JAIDS, 2011 [4] 614 men 5 – 12 years Older age (≥50 years) ↓ CD4+ T-cell counts by 59 cells/μl over 5-12 years
Greenbaum, AIDS, 2008 [2] 906 4 years Nonsignificant difference in time to increase by 50 cells/μL or mean increase in CD4+ T-cells from baseline between > 50 years vs. < 40 years
Wright et al., HIV medicine, 2013 [6] 3378 ≥ 5 years Nonsignificant difference in CD4+ T-cell increase rate in > 50 years vs. others