The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study

Table 3 Pre-selected parameter-covariate relationships

Parameters	Covariates to be included in SCM
σ [(cell/μL)*year⁻¹]	Age, ART class, viral load, sex, BMI, race
d_N (year*cell/μL)⁻¹	Age, ART class, viral load, sex, smoking status
α (year⁻¹)	Age, CD4+ T-cell immune activation, CD8+ T-cell immune activation, smoking status, viral load
d_M (year*cell/μL)⁻¹	Age, ART class, CD4+ T-cell immune activation, CD8+ T-cell immune activation, sex, smoking status
Baseline_N (cell/μL)	Age, CD4+ T-cell immune activation, CD8+ T-cell immune activation, viral load, sex
Baseline_M (cell/μL)	Age, CD4+ T-cell immune activation, CD8+ T-cell immune activation, race, sex

σ: production rate of naïve T-cells, α: activation rate constant, d_N: naïve T-cell death rate constant of naïve T-cells that acquire a memory phenotype, d_M: memory T-cell death rate constant, baseline_N,baseline_M: naïve or memory T-cell count at ART initiation
ART antiretroviral therapy, BMI body mass index, SCM stepwise covariate modeling

ISSN: 1742-4933