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Table 3 Pre-selected parameter-covariate relationships

From: The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study

Parameters Covariates to be included in SCM
σ [(cell/μL)*year−1] Age, ART class, viral load, sex, BMI, race
dN (year*cell/μL)−1 Age, ART class, viral load, sex, smoking status
α (year−1) Age, CD4+ T-cell immune activation, CD8+ T-cell immune activation, smoking status, viral load
dM (year*cell/μL)−1 Age, ART class, CD4+ T-cell immune activation, CD8+ T-cell immune activation, sex, smoking status
BaselineN (cell/μL) Age, CD4+ T-cell immune activation, CD8+ T-cell immune activation, viral load, sex
BaselineM (cell/μL) Age, CD4+ T-cell immune activation, CD8+ T-cell immune activation, race, sex
  1. σ: production rate of naïve T-cells, α: activation rate constant, dN: naïve T-cell death rate constant of naïve T-cells that acquire a memory phenotype, dM: memory T-cell death rate constant, baselineN,baselineM: naïve or memory T-cell count at ART initiation
  2. ART antiretroviral therapy, BMI body mass index, SCM stepwise covariate modeling