Parameter (units) | Estimates (RSE%) | Bootstrap estimates | |||
---|---|---|---|---|---|
Point estimates | RSE (%) | Median | 95% CI | ||
σ [(cell/μL) • year− 1] | 703 | 19 | 700 | (484, 1006) | |
dN (year • cell/μL)− 1 | 0.0410 | 22 | 0.0410 | (0.0255, 0.0661) | |
dM (year • cell/μL)−1 | 0.000432 | 13 | 0.000435 | (0.000314, 0.000559) | |
α (year−1) | 1.10 | 13 | 1.11 | (0.85, 1.45) | |
baselineN (cell/μL) | 30.5 | 13 | 29.8 | (20.3, 38.9) | |
baselineM (cell/μL) | 211 | 10 | 210 | (173, 250) | |
Covariate Effects | |||||
VL-BaselineM | −0.422 | 20 | −0.424 | (−0.552, − 0.174) | |
IACD4-BaselineM | − 0.378 | 18 | −0.375 | (− 0.435, − 0.138) | |
VL-BaselineN | − 0.648 | 3.8 | − 0.645 | (− 0.733, − 0.477) | |
Age-dN | 0.0389 | 37 | 0.0394 | (0.0124, 0.0514) | |
Sex-dM (Female) | −0.48 | 25 | −0.485 | (− 0.664, − 0.212) | |
Inter-individual variability (CV%) | Shrinkage (%) | ||||
σ | 116 | 7.3 | 7.5 | 115 | (99.7, 136) |
dN | 63.7 | 20 | 41 | 63.4 | (28.9, 82.7) |
dM | 59.9 | 14 | 38 | 57.7 | (37.3, 78.2) |
α | 125 | 9.8 | 5.8 | 123 | (97.3, 148) |
baselineN | 135 | 8.9 | 9.3 | 137 | (105, 165) |
baselineM | 85.8 | 9.5 | 32 | 83.6 | (68.5, 101) |
cor(ω2σ ~ ω2α) | −0.802 | 7.2 | – | −0.805 | (−0.913, −0.679) |
Residual variability (CV%/SD) | |||||
Total, proportional | 16.3 | 3.3 | 6.9 | 16.3 | (15.2, 17.3) |
Total, additive | 31.2 | 22 | 18 | 31.7 | (15.4, 44.9) |
Naive, proportional | 42.1 | 6.6 | 15 | 41.5 | (35.7, 46.7) |
Naive, additive | 2.03 | 14 | 23 | 2.01 | (1.19, 2.68) |