Skip to main content

Table 5 Final parameter estimates

From: The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study

Parameter (units) Estimates (RSE%) Bootstrap estimates
Point estimates RSE (%)   Median 95% CI
σ [(cell/μL) • year− 1] 703 19   700 (484, 1006)
dN (year • cell/μL)− 1 0.0410 22   0.0410 (0.0255, 0.0661)
dM (year • cell/μL)−1 0.000432 13   0.000435 (0.000314, 0.000559)
α (year−1) 1.10 13   1.11 (0.85, 1.45)
baselineN (cell/μL) 30.5 13   29.8 (20.3, 38.9)
baselineM (cell/μL) 211 10   210 (173, 250)
Covariate Effects
 VL-BaselineM −0.422 20   −0.424 (−0.552, − 0.174)
 IACD4-BaselineM − 0.378 18   −0.375 (− 0.435, − 0.138)
 VL-BaselineN − 0.648 3.8   − 0.645 (− 0.733, − 0.477)
 Age-dN 0.0389 37   0.0394 (0.0124, 0.0514)
 Sex-dM (Female) −0.48 25   −0.485 (− 0.664, − 0.212)
Inter-individual variability (CV%) Shrinkage (%)   
 σ 116 7.3 7.5 115 (99.7, 136)
 dN 63.7 20 41 63.4 (28.9, 82.7)
 dM 59.9 14 38 57.7 (37.3, 78.2)
 α 125 9.8 5.8 123 (97.3, 148)
 baselineN 135 8.9 9.3 137 (105, 165)
 baselineM 85.8 9.5 32 83.6 (68.5, 101)
 cor(ω2σ ~ ω2α) −0.802 7.2 −0.805 (−0.913, −0.679)
Residual variability (CV%/SD)    
 Total, proportional 16.3 3.3 6.9 16.3 (15.2, 17.3)
 Total, additive 31.2 22 18 31.7 (15.4, 44.9)
 Naive, proportional 42.1 6.6 15 41.5 (35.7, 46.7)
 Naive, additive 2.03 14 23 2.01 (1.19, 2.68)
  1. σ: production rate of naïve T-cells, α: activation rate constant of naïve T-cells into memory phenotype, dN: apparent naïve T-cell elimination rate constant, dM: apparent memory T-cell elimination rate constant, baselineN: naïve T-cell count at ART initial, baselineM: memory T-cell count at ART initial, VL: HIV viral load (log10RNA/mL), IACD4: CD4+ T-cell activation
  2. T-cell activation is defined by %CD38/HLA-DR, and is analyzed as log-transformed values
  3. CV coefficient of variance, CI confidence interval, RSE relative standard error