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Table 5 Final parameter estimates

From: The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study

Parameter (units)

Estimates (RSE%)

Bootstrap estimates

Point estimates

RSE (%)

 

Median

95% CI

σ [(cell/μL) • year− 1]

703

19

 

700

(484, 1006)

dN (year • cell/μL)− 1

0.0410

22

 

0.0410

(0.0255, 0.0661)

dM (year • cell/μL)−1

0.000432

13

 

0.000435

(0.000314, 0.000559)

α (year−1)

1.10

13

 

1.11

(0.85, 1.45)

baselineN (cell/μL)

30.5

13

 

29.8

(20.3, 38.9)

baselineM (cell/μL)

211

10

 

210

(173, 250)

Covariate Effects

 VL-BaselineM

−0.422

20

 

−0.424

(−0.552, − 0.174)

 IACD4-BaselineM

− 0.378

18

 

−0.375

(− 0.435, − 0.138)

 VL-BaselineN

− 0.648

3.8

 

− 0.645

(− 0.733, − 0.477)

 Age-dN

0.0389

37

 

0.0394

(0.0124, 0.0514)

 Sex-dM (Female)

−0.48

25

 

−0.485

(− 0.664, − 0.212)

Inter-individual variability (CV%)

Shrinkage (%)

  

 σ

116

7.3

7.5

115

(99.7, 136)

 dN

63.7

20

41

63.4

(28.9, 82.7)

 dM

59.9

14

38

57.7

(37.3, 78.2)

 α

125

9.8

5.8

123

(97.3, 148)

 baselineN

135

8.9

9.3

137

(105, 165)

 baselineM

85.8

9.5

32

83.6

(68.5, 101)

 cor(ω2σ ~ ω2α)

−0.802

7.2

−0.805

(−0.913, −0.679)

Residual variability (CV%/SD)

   

 Total, proportional

16.3

3.3

6.9

16.3

(15.2, 17.3)

 Total, additive

31.2

22

18

31.7

(15.4, 44.9)

 Naive, proportional

42.1

6.6

15

41.5

(35.7, 46.7)

 Naive, additive

2.03

14

23

2.01

(1.19, 2.68)

  1. σ: production rate of naïve T-cells, α: activation rate constant of naïve T-cells into memory phenotype, dN: apparent naïve T-cell elimination rate constant, dM: apparent memory T-cell elimination rate constant, baselineN: naïve T-cell count at ART initial, baselineM: memory T-cell count at ART initial, VL: HIV viral load (log10RNA/mL), IACD4: CD4+ T-cell activation
  2. T-cell activation is defined by %CD38/HLA-DR, and is analyzed as log-transformed values
  3. CV coefficient of variance, CI confidence interval, RSE relative standard error