|
Parameter (units)
|
Estimates (RSE%)
|
Bootstrap estimates
|
|---|
|
Point estimates
|
RSE (%)
| |
Median
|
95% CI
|
|---|
|
σ [(cell/μL) • year− 1]
|
703
|
19
| |
700
|
(484, 1006)
|
|
dN (year • cell/μL)− 1
|
0.0410
|
22
| |
0.0410
|
(0.0255, 0.0661)
|
|
dM (year • cell/μL)−1
|
0.000432
|
13
| |
0.000435
|
(0.000314, 0.000559)
|
|
α (year−1)
|
1.10
|
13
| |
1.11
|
(0.85, 1.45)
|
|
baselineN (cell/μL)
|
30.5
|
13
| |
29.8
|
(20.3, 38.9)
|
|
baselineM (cell/μL)
|
211
|
10
| |
210
|
(173, 250)
|
|
Covariate Effects
|
|
VL-BaselineM
|
−0.422
|
20
| |
−0.424
|
(−0.552, − 0.174)
|
|
IACD4-BaselineM
|
− 0.378
|
18
| |
−0.375
|
(− 0.435, − 0.138)
|
|
VL-BaselineN
|
− 0.648
|
3.8
| |
− 0.645
|
(− 0.733, − 0.477)
|
|
Age-dN
|
0.0389
|
37
| |
0.0394
|
(0.0124, 0.0514)
|
|
Sex-dM (Female)
|
−0.48
|
25
| |
−0.485
|
(− 0.664, − 0.212)
|
|
Inter-individual variability (CV%)
|
Shrinkage (%)
| | |
|
σ
|
116
|
7.3
|
7.5
|
115
|
(99.7, 136)
|
|
dN
|
63.7
|
20
|
41
|
63.4
|
(28.9, 82.7)
|
|
dM
|
59.9
|
14
|
38
|
57.7
|
(37.3, 78.2)
|
|
α
|
125
|
9.8
|
5.8
|
123
|
(97.3, 148)
|
|
baselineN
|
135
|
8.9
|
9.3
|
137
|
(105, 165)
|
|
baselineM
|
85.8
|
9.5
|
32
|
83.6
|
(68.5, 101)
|
|
cor(ω2σ ~ ω2α)
|
−0.802
|
7.2
|
–
|
−0.805
|
(−0.913, −0.679)
|
|
Residual variability (CV%/SD)
| | | |
|
Total, proportional
|
16.3
|
3.3
|
6.9
|
16.3
|
(15.2, 17.3)
|
|
Total, additive
|
31.2
|
22
|
18
|
31.7
|
(15.4, 44.9)
|
|
Naive, proportional
|
42.1
|
6.6
|
15
|
41.5
|
(35.7, 46.7)
|
|
Naive, additive
|
2.03
|
14
|
23
|
2.01
|
(1.19, 2.68)
|
- σ: production rate of naïve T-cells, α: activation rate constant of naïve T-cells into memory phenotype, dN: apparent naïve T-cell elimination rate constant, dM: apparent memory T-cell elimination rate constant, baselineN: naïve T-cell count at ART initial, baselineM: memory T-cell count at ART initial, VL: HIV viral load (log10RNA/mL), IACD4: CD4+ T-cell activation
- T-cell activation is defined by %CD38/HLA-DR, and is analyzed as log-transformed values
- CV coefficient of variance, CI confidence interval, RSE relative standard error
