From: Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis
N | TL (z-score)1 | p | <Percentile 10th n (%) | p | |
---|---|---|---|---|---|
Healthy Controls | 68 | −0.00 [− 0.28, 0.31] | Ref | 6 (9%) | Ref |
SSc patients | 174 | −0.84 [−1.15, − 0.62] | < 0.0001 | 71 (41%) | < 0.0001 |
dcSSc | 69 | −0.84 [−1.93, 0.05] | < 0.0001 | 29 (42%) | < 0.0001 |
lcSSc | 105 | −0.85 [−1,57, 0,18] | < 0.0001 | 40 (38%) | 0.0001 |
ILD | 57 | −1.03 [− 1.63, −0.42] | < 0.0001 | 24 (41%) | < 0.0001 |
No ILD | 117 | −0.83 [−1.62, 0.32] | 0.004 | 45 (39%) | 0.0001 |
ATA+ | 54 | −1.04 [− 1.6, −0.03] | 0.0002 | 22 (41%) | < 0.0001 |
ACA+ | 62 | −0,63 [−1.30, 0.47] | 0.025 | 20 (32%) | 0.0008 |
Comorbidity2 | 115 | −0.85 [−1.58, 0.18] | 0.0001 | 44 (38%) | < 0.0001 |
No comorbidity | 59 | −0.84 [−2.06, − 0.02] | 0.0003 | 27 (28%) | < 0.0001 |