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Fig. 3 | Immunity & Ageing

Fig. 3

From: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial

Fig. 3

Changes in osteonectin, IL-6, IL-15 and IL-7, prominent myokines, are related to changes in immune cell subsets with exercise. A, B Changes in osteonectin and IL-6 were negatively related to changes in CD4 N T cells and CD4 T cells in the HIIT group only, respectively. C,D Changes in IL-15 were negatively related to changes in CD4 EM T cells in the HIIT group only; and negatively related to changes in CD8 EMRA T cells in the MICT group only. E, F Changes in osteonectin were negatively related to changes in β2-AR expression CD8 EM T cells and positively related to changes in the β2-AR expression on NK cells, respectively, in the MICT group only. G, F Changes in IL-7 were positively related to changes in β2-AR expression on CD4 N T cells and β2-AR expression on CD4 T cells in the exercise (HIIT+MICT; respectively) groups only. N=naïve, CM=central memory, EM=effector memory, EMRA=Effector Memory CD45RA+. Lines represent line of best fit and were analyzed by Pearson’s Correlation with p<0.05 considered statistically signification. *p<0.05

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