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Table 4 Differences in the proportions of immune cell types between EBV expression positive and negative samples

From: Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging

Cell type

EBV pos median %

EBV neg median %

p-value

B cells, naive

5.73

5.04

0.971

B cells, memory

0.00

0.00

0.287

Plasma cells

3.41

2.88

0.185

T cells, CD8

2.41

2.34

0.985

T cells, CD4 naive

4.57

4.44

0.823

T cells, CD4 memory resting

5.01

7.48

0.389

T cells, CD4 memory activated

3.65

2.24

0.096

T cells, follicular helper

0.00

0.00

0.419

T cells, regulatory

0.00

0.15

0.291

T cells, gamma delta

1.08

0.00

0.432

NK cells, resting

7.17

7.79

0.354

NK cells, activated

0.00

0.00

0.620

Monocytes

9.79

6.23

0.235

Macrophages, M0

3.49

2.42

0.422

Macrophages, M1

0.00

0.53

0.043

Macrophages, M2

0.00

0.00

0.987

Dendritic cells, resting

0.96

0.78

0.696

Dendritic cells, activated

2.91

1.67

0.004

Mast cells, resting

3.01

1.04

0.187

Mast cells, activated

0.00

0.10

0.007

Eosinophils

0.75

0.74

0.848

Neutrophils

6.52

5.04

0.256

  1. Each of the 22 functionally defined human hematopoietic cell subsets included in the CIBERSORTx LM22 data were tested using non-parametric Mann-Whitney U-test. Of the 215 samples for which CIBERSORTx provided a high confidence deconvolution result, 43 samples had EBV expression compared to the 172 samples that did not. CIBERSORTx results are given as relative proportions of the 22 cell types and the median values for EBV expression positive and negative samples for each cell type are shown in this table as percentages. The cell types with significant p-values are shown in bold