Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics

Immunity & Ageing

Table 1 Genes targeted on smMIPs assay and proportion of CHIP in population covered by these target regions

Gene name	Target size (bp)	MIPS read depth		% of CHIP in Population^b
Gene name	Target size (bp)	Median	Mean	% of CHIP in Population^b
ASXL1	4687	2054	3891	7.41%
CBL	2803	4880	6845	0.62%
DNMT3A	3071	3163	4325	45.97%
GNB1	1023	4671	6139	0.97%
PPM1D	1894	3889	4856	4.01%
SF3B1	4045	3936	5073	2.46%
TET2	6165	2033	3587	19.13%
TP53	1714	4063	5543	1.97%
U2AF1	880	4403	6126	0.23%
ZBTB33	2019	1983	2632	2.22%
ZNF318	6918	3240	4765	1.80%
SRSF2^a	1	289	512	1.88%
IDH1^a	1	1325	1797	0.09%
IDH2^a	1	3029	3909	0.30%
JAK2^a	1	3839	4944	1.65%
Overall	35,223 bp	2803	4480	88.83%

^aSRSF2, IDH1, IDH2, JAK2 target a single hotspot mutation
^bPopulation frequencies of CHIP previously reported in NHLBI TOPMed cohorts [6]

ISSN: 1742-4933